Janice, I don't know that it's possible to tell if any of these 'work' -- if we all live 'til we're 85, cancer-free, sprightly and sharp-witted, then we might guess it was the CoQ10 or extra B vitamins or maybe just happy thoughts or lively companions that we can thank.
Even if we do get extra years, causation is impossible to attribute to any one substance or activity when our lives were so long and complex! If you read six studies that say, in double-blind tests, such and such happened for 75% of people taking some pill (OTC or prescription, for that matter), there are still 100 other explanations than "pill cured condition" for that result. If X pill did cure anything (especially obesity), millions would be taking it and everyone would clearly know that result.
As for me, nothing (including CoQ10) I've taken has sped fat loss, nothing has made me feel better in any sense, nothing has cured my PMS, and no pill or cream has made me look 15 years younger. Feverfew may have gotten rid of 10% of migraines, but I can't swear to that, either (could have been a random association, as migraines ease up and get worse periodically.) Despite my skepticism, I do hear St John's Wort works for mild depression. Depression is, however, very sensitive to the placebo effect.
If Vitamin E is a good, inexpensive substitute, as Doreen says, sounds like a good place to start.