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  #1   ^
Old Tue, Aug-28-18, 09:46
teaser's Avatar
teaser teaser is offline
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Default High-sugar feeding only at active times of day reduces adverse effects in rats

https://www.sciencedaily.com/releas...80827100431.htm

Quote:
A sedentary lifestyle combined with a diet dominated by processed foods has widely resulted in a range of conditions including diabetes, obesity, and high blood pressure, which are known collectively as metabolic syndrome. Although many insights into the causes of metabolic syndrome have been made, much remains to be understood about the complex interplay among the genetic, environmental, and lifestyle-related factors related to ways of preventing this condition.

Sucrose, a common form of sugar made up of glucose and fructose, is one part of the diet known to be associated with conditions such as obesity and high blood pressure when consumed in excess. However, it is still somewhat unclear how this occurs and how to minimize it. In a new paper published in PLOS ONE, a research team centered at Nagoya University has shown that restricting the consumption of a high-sucrose diet in rats to the part of the day when they are active avoids many of the deleterious effects of excess sugar on the body.

The team established four groups of rats with different diets: either a high-sucrose diet or an equivalent diet with starch replacing the sucrose, with these being made available either throughout the day and night, or only when the rats were active. Given the nocturnal nature of rats, this corresponded to the nighttime.

"We chose to study rats because their body weight is ten times that of the commonly used animal model of mice, making them more similar to humans, and because they have a more stable metabolism" Hiroaki Oda of the Laboratory of Nutritional Biochemistry says. "We subjected the four groups to various analyses, including of body weight, lipids in blood and liver, and hepatic gene expression."

The results showed that, when the rats had access to high-sucrose food only at night when they were active, their levels of fat in the blood and liver were lower than those in the group in which such food was available all the time, despite the two groups consuming the same amount overall. The results also indicated that this improvement was not caused by any knock-on effect on the expression of genes for fat metabolism, indicating that it was the temporal restriction on feeding itself that produced the beneficial effects.

"Our findings could be very important for the fight against obesity and other lifestyle-related diseases in humans," lead author Shumin Sun says. "Potentially, limiting sugar intake to the part of the day when people are most active could reduce many of the damaging effects of its excessive consumption across the globe."



Quote:
A sedentary lifestyle combined with a diet dominated by processed foods has widely resulted in a range of conditions including diabetes, obesity, and high blood pressure, which are known collectively as metabolic syndrome.


First, start with the CICO mantra that will keep you from being mauled the second you step outside the lab...

Quote:
Although many insights into the causes of metabolic syndrome have been made, much remains to be understood about the complex interplay among the genetic, environmental, and lifestyle-related factors related to ways of preventing this condition.


Then point out, gently, that it's not that simple.

Quote:
We chose to study rats because their body weight is ten times that of the commonly used animal model of mice, making them more similar to humans


Umm...
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  #2   ^
Old Tue, Aug-28-18, 10:42
Zei Zei is offline
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Disappointing the article didn't also include the results from the high starch arm of the study. Did rats receiving high starch diets only during active times also show the same benefits as the feeding-time equivalent animals on the high sugar chow? Or were all high-starch rats unaffected by the problems sugar-fed rats developed? Two different things going on; high sugar versus starch plus eating time of day/intermittent fasting window. I wonder what the total results showed?
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  #3   ^
Old Tue, Aug-28-18, 11:24
teaser's Avatar
teaser teaser is offline
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Plan: mostly milkfat
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http://journals.plos.org/plosone/ar...al.pone.0201261

The study itself is free access. Looks like there wasn't much effect of the timing window on the starch-based control diets.

The metabolic syndrome markers seem to go in the same direction with control vs. control restricted as with the two high sugar groups--but I haven't read carefully enough to speak to statistical significance. At any rate, generally the numbers given are better for the control diet whether time restricted or not than for the high sugar diets.
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