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  #1   ^
Old Tue, Aug-07-18, 20:24
teaser's Avatar
teaser teaser is offline
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Posts: 13,185
Plan: mostly milkfat
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Location: Ontario
Default keto and mood disorders

Brietzke E1, Mansur RB2, Subramaniapillai M2, Martinez VB3, Vinberg M4, González-Pinto A5, Rosenblat JD2, Ho R6, McIntyre RS7.
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Despite significant advances in pharmacological and non-pharmacological treatments, mood disorders remain a significant source of mental capital loss, with high rates of treatment resistance, requiring a coordinated effort in investigation and development of efficient, tolerable and accessible novel interventions. Ketogenic diet (KD) is a low-carb diet that substantially changes the energetic matrix of the body including the brain. It has been established as an effective anticonvulsant treatment, and more recently, the role of KD for mental disorders has been explored. Ketogenic diet has profound effects in multiple targets implicated in the pathophysiology of mood disorders, including but not limited to, glutamate/GABA transmission, monoamine levels, mitochondrial function and biogenesis, neurotrophism, oxidative stress, insulin dysfunction and inflammation. Preclinical studies, case reports and case series have demonstrated antidepressant and mood stabilizing effects of KD, however, to date, no clinical trials for depression or bipolar disorder have been conducted. Because of its potential pleiotropic benefits, KD should be considered as a promising intervention in research in mood disorder therapeutics, especially in treatment resistant presentations.

There's tremendous overlap in medication that's effective both for epilepsy and bipolar. That alone should be enough to suggest taking a look at ketogenic diets. Good to see that somebody's at least calling for studies/hoping for funding in the area.
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  #2   ^
Old Tue, Aug-07-18, 20:38
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Ms Arielle Ms Arielle is offline
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Plan: atkins
Stats: 247/217/153 Female 5'8"
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IMO We are way behind in the area of mental health and all its permutations. The impact of diet, supplements, sleep, and a myriad of other factors that are supportive is long overdue.

The little I understand about bi-polar is that it is rather complex and requires thought and care to get the brain balanced, and then keep it balanced. Dr AMen wrote a detailed chapter that was insightful in Healing ADD, and he suggests a low carb diet for support .

With his years of clinical experience, perhaps he has published papers on this. He has 5 clinics and given the staff at each facility, the names on the paper could be any one of these doctors.
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  #3   ^
Old Wed, Aug-08-18, 09:18
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JEY100 JEY100 is offline
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Posts: 10,730
Plan: IF Fung/LC Westman/Primal
Stats: 222/171/169 Female 5' 9"
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DietDoctor added this study, and their previous posts on same topic.
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