Quote:
Originally Posted by Samuel
In a chemical reaction the total weight of all materials entering the reaction must be equal to the total weight of all materials resulting from the reaction.
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The rule used to be that matter was neither created nor destroyed. Einstein changed the perception of that. But the fact remains that, outside of nuclear reactions which we don't ordinarily experience -- except for the sun, of course -- and outside of phenomena that take place under extraordinary circumstances, such as travelling close to the speed of light, it is safe to assume that matter is stable. Further, atoms don't change from one kind of atom to another in chemical reactions, they only bond or break bonds with each other, and the making and breaking of these bonds can absorb or release bonding energy.
But the core of the debate that rages on is this idea that "a calorie is a calorie." The meaning of this seems to be that dietary composition does not matter, what matters is how many calories you consume. If you are on a diet that keeps your weight stable, and you change the composition of that diet, substituting, say, fat calories for carbohydrate calories, you won't, it is claimed, lose weight. Someone who wants to promote the "calorie is a calorie" idea is free to come up with a better explanation.
But the problem is that there is a huge and very common misconception: that food "calories" are units of energy. Not exactly. Rather, they have been modified from energy calories by a factor, called the Atwater factor, that is supposed to account for the differences in the way in which the body metabolizes them. This factor varies with the kind of food. The original work was done, as I recall, over 100 years ago; more recent work has shown that Atwater factors aren't exact; among other things, it appears that there are factors in the diet which can change the way in which the body treats a food.
The following is from the American Journal of Clinical Nutrition, an article entitled "Is a calorie a calorie?",
http://www.ajcn.org/cgi/content/full/79/5/899S
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The Atwater general factors, however, continue to be commonly used. In 1970 Southgate and Durnin (27) tested the Atwater general factors and determined that they were still valid, with one exception. Large amounts of unavailable dietary carbohydrate resulted in increased excretion of fecal fat, nitrogen, and energy, and these findings were subsequently confirmed by other researchers (28–31). Thus, Southgate and Durnin (27) found that the Atwater protein and fat factors overestimate the energy derived from these constituents. Others have since found that the Atwater general factors overestimate the measured metabolizable energy of mixed diets, especially those high in dietary fiber, by a mean (±SD) of 6.7 ± 4.4% (range: 1.2–18.1%) (28–30, 32–35). The reasons hypothesized to explain the effect of dietary fiber on metabolizable energy are many. Dietary fiber may decrease the transit time of food in the intestine (resulting in less time for digestion and absorption), increase bulk and water-holding capacity (reducing the rate of diffusion of digestion products toward the intestinal mucosal surface for absorption), or cause mechanical erosion of the mucosal surface (leading to increased endogenous material) (29, 36). Wisker and Feldheim (28) also note that in contrast with the energy content of protein and fat, the energy content of dietary fiber is liberated by fermentation. Thus, factors affecting the microbial degradation of dietary fiber—the chemical structure of nonstarch polysaccharides, the solubility and degree of lignification of the fiber components, and physiologic factors such as the composition of the colon microflora and the transit time—may affect metabolizable energy (28). This may be the reason why the Atwater general factors were found to overestimate measured metabolizable energy to a greater extent for diets high in nonavailable fiber than for diets high in available fiber (overestimations of 7.0% and 2.6%, respectively; P < 0.05) (35). Together, findings from the above studies show that not all dietary carbohydrates provide 4 kcal/g.
The differences between the general Atwater factors, the specific Atwater factors, and true metabolizable energy might explain some of the difference in weight loss observed after consumption of 2 diets with different fiber content.
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In other words, fiber in the diet, for example, may result in changes in the effective energy release from other foods.
If "a calorie is a calorie," it would be because the differences in the utilizability by the body of oxidation calories in foods have been factored into food label calories, based on very old measurements of the factors for different foods. There are *very* many ways for this to go wrong.
I'm not knowledgeable enough to know what work has been done, but I would assume that there might be differences from person to person, for example, in how efficiently people handle calories, how efficiently they convert one kind of nutrient to another (as, for example, carbs to stored fat), and, further, that there could be all kinds of interactions between foods, not just between fiber and other foods as described in the quoted material.
To imagine, as some have done, that "a calorie is a calorie" is an immutable law of thermodynamics, when speaking of food calories, is to be seriously deluded. For some reason, there are plenty of sources which explain food calories and which completely neglect the Atwater factors, so it is easy to forgive a lay person for erring with regard to this. But for a nutrition expert to make this mistake is.... appalling.
Quite obviously, the thermodynamic calories contained in foods (i.e., how much energy is released when you literally burn them) and the energy that those foods make available to the body are not the same. The thermodynamic energy is essentially the *maximum* energy that the body can extract from the foods by oxidation. I.e., by combining them with oxygen, which is how we obtain energy from food; we are slow flames. Sort of.
The food calories that we find on labels have been reduced by a factor based on experiment, calculation, and assumption so that food calories can be compared from one food to another. Again, sort of. It is not exact, and might even be pretty far off in some cases.
The article concludes, oddly, with a reaffirmation of "a calorie is a calorie," which is strange, because it has shown that this is not true, when we are talking about food calories. Still, it's worth reading! This is the conclusion:
*Begin quote*
We conclude that a calorie is a calorie. From a purely thermodynamic point of view, this is clear because the human body or, indeed, any living organism cannot create or destroy energy but can only convert energy from one form to another. In comparing energy balance between dietary treatments, however, it must be remembered that the units of dietary energy are metabolizable energy and not gross energy. This is perhaps unfortunate because metabolizable energy is much more difficult to determine than is gross energy, because the Atwater factors used in calculating metabolizable energy are not exact. As such, our food tables are not perfect, and small errors are associated with their use.
In addition, we concede that the substitution of one macronutrient for another has been shown in some studies to have a statistically significant effect on the expenditure half of the energy balance equation. This has been observed most often for high-protein diets. Evidence indicates, however, that the difference in energy expenditure is small and can potentially account for less than one-third of the differences in weight loss that have been reported between high-protein or low-carbohydrate diets and high-carbohydrate or low-fat diets. As such, a calorie is a calorie. Further research is needed to identify the mechanisms that result in greater weight loss with one diet than with another.
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