Epobee,
do me a favor and don't ever embark on a career in science journalism, because you really have no idea how to get your facts right.
Re the Stefannson and Anderson Bellevue Hospital experiment, you write that they ate:
"hmmm...a pound and a third of lean meat per day (1 1/3 lbs = 600 grams = 2400 calories) + a half pound of fat (.5 lbs. = 225 grams = 2000 calories) = 4400 calories/day. they both lost weight."
Crikey…
I have the paper right here (JAMA, July 6, 1929; 93 (1): 20-23), and it says, I quote:
"Steffansson averaged about 2,650 calories a day…Anderson averaged about 2,620 calories a day."
Hmmm…
These guys were not highly active during the study (not that you would know, because you obviously have not read it)--if they had consumed the 4400 calories/day figure that you pulled out of goodness knows where, they would have put on weight REAL QUICK!!
You write:
"however, if you look at kekwick's study, you'll see that those on 1000-calorie high-carb diet, did not lose weight. in this case, there was a calorie-deficit, but no weight loss. how do you reconcile that with the laws of thermodynamics? would you suggest that these people were expending less than 1000-calories/day? or maybe this wasn't "tightly-controlled" enough."
You stoop to the shady practice of selective citation when you cite Kekwick and Pawan's study, which you claim showed no weight loss on a cal-restricted low-fat diet. You ignore the dozens of trials that HAVE shown weight loss on such a diet!
The Kekwick and Pawan trial, although a favorite citation of low-carb supporters, is one of the great garbage weight loss trials of all time--it really tells us nothing of value, because it was a very short, poorly-controlled affair.
The authors even went to the unusual step of complaining about the very poor compliance of the subjects in their paper, writing that the study participants would "…cheat and lie, obtaining food from visitors, from trolleys touring the wards, and from neighbouring patients…the results we report are selected…"
This is your support for your dissent of the importance of the calorie equation? A single poorly-controlled study from the 1950's?!
Furthermore, the 1000-calorie portion of the experiment lasted only 7 days. It has been shown repeatedly since that water loss accounts for the bulk of the difference in weight loss between hi-carb and low-carb diets during this time…again you wouldn't know that because you simply have not taken the time to scrupulously examine the literature, have you? My advice…take a break from spouting unfounded nonsense on this otherwise fine forum, locate your nearest medical library, and start familiarizing yourself with the literature!
You also write:
"as far as uncovering tightly-controlled clinical trials that demonstrate weight-loss without calorie deficit, forget it. first, show me a tightly-controlled clinical trial that demonstrates weight-loss with a calorie deficit."
You want trials showing weight loss with calorie restriction? I can't believe you even need to ask for this, but what the heck, here are some, hopefully you'll bother to take the advice I just gave above, track these studies down and actually read them:
Baron JA, et al. A randomized controlled trial of low carbohydrate and low fat/high fiber diets for weight loss. American Journal of Public Health, 1986; 76 (11): 1293-1296.
Wadden TA. Treatment of obesity by moderate and severe caloric restriction. Annals of Internal Medicine, Oct. 1993; 119 (7, Pt. 2): 688-693.
Foreyt JP, Goodrick GK. Evidence for success of behavior modification in weight loss and control. Annals of Internal Medicine, Oct. 1993; 119 (7, Pt. 2): 698-701.
Alford BB, et al. The effects of variations in carbohydrate, protein, and fat content of the diet upon weight loss, blood values, and nutrient intake of adult obese women. Journal of the American Dietetic Association, 1990; 90: 534-540.
Racette SB, et al. Effects of aerobic exercise and dietary carbohydrate on energy expenditure and body composition during weight reduction in obese women. American Journal of Clinical Nutrition, 1995; 61: 486-494.
Golay A, et al. Weight-Loss With Low or High Carbohydrate Diet? International Journal of Obesity, 1996; 20 (12): 1067-1072.
Golay A, et al. Similar weight loss with low- or high carbohydrate diets. American Journal of Clinical Nutrition, 1996; 63: 174-178.
Lean ME, et al. Weight loss with high and low carbohydrate 1200 kcal diets in free living women. European Journal of Clinical Nutrition, Apr. 1997; 51 (4): 243-248.
Torbay N, et al. High protein vs high carbohydrate hypoenergetic diet in treatment of obese normoinsulinemic and hyperinsulinemic subjects. Nutrition Research, May 2002; 22 (5): 587-598.
Layman DK, et al. A reduced ratio of dietary carbohydrate to protein improves body composition and blood lipid profiles during weight loss in adult women. Journal of Nutrition, 2003; 133: 411-417.
Layman DK. The role of leucine in weight loss diets and glucose homeostasis. Journal of Nutrition, 2003; 133: 261S-267S.
Sondike SB, et al. Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factors in overweight adolescents. Journal of Pediatrics, March 2003; 142: 253-258.
Volek JS, et al. Body composition and hormonal responses to a carbohydrate-restricted diet. Metabolism, July 2002; 51 (7): 864-870.
Brehm, et al. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. Journal of Clinical Endocrinology and Metabolism, 2003; 88 (4): 1617-1623.
Wien MA, et al. Almonds vs complex carbohydrates in a weight reduction program.. International Journal of Obesity and Related Metabolic Disorders, Nov 2003; 27 (11): 1365-1372.
Foster GD, et al. A randomized trial of a low-carbohydrate diet for obesity. New England Journal of Medicine, May 22, 2003; 348: 2082-2090.
Samaha FF, et al. A low-carbohydrate diet as compared with a low fat diet in severe obesity. New England Journal of Medicine, May 22, 2003; 348: 2074-2081.
Stern L, et al. The Effects of Low-Carbohydrate versus Conventional Weight Loss Diets in Severely Obese Adults: One-Year Follow-up of a Randomized Trial. Annals of Internal Medicine, 2004; 140: 778-785.
Yancy WS, et al. A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia: A Randomized, Controlled Trial. Annals of Internal Medicine, 2004; 140: 769-777.
Johnston CS, et al. High-protein, low-fat diets are effective for weight loss and favorably alter biomarkers in healthy adults. Journal of Nutrition, Mar, 2004; 134 (3): 586-591.
Puhleeez, get your facts right…
Anthony Colpo
www.theomnivore.com