Quote:
Originally Posted by GRB5111
I realize that this study isn't intended to be humorous, but I can't help but laughing at the lack of awareness of discreet metabolic mechanisms going into this. If the desired outcome is good, then full speed ahead, forget all the other stuff.
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I actually had to read the following part of the quote a couple of times (early morning, brain wasn't firing on all cylinders yet), before I noticed that it was it a mouse study (and therefore quite likely not even relevant to humans).
Quote:
In the study reported in Nanomedicine, mice were fed high fat, high calorific diets, to induce weight gain, mixed with specially engineered MSPs. The results showed that MSPs reduced food efficiency by 33 percent leading to a lower weight gain, and a positive effect on the metabolic profile, as well as significant lower levels of adipose tissue formation and leptin, together with lower levels of circulating insulin.
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But what really got me was that even not knowing exactly what macro percentages they fed the mice, there was the fact that the mice had such good results controlling insulin, and lower weight gain than expected, considering the high calories. How much of that could be attributed to the MSPs, and how much to the diet itself? Do they know or care that it's not just about calories in/calories out?
I think someone up there pointed out that they didn't even say whether the MSPs absorbed calories from fats, protein, or carbs - but given the better metabolic improvement and lower insulin levels, my guess is that it really only affected carb absorption.
Are they living in such a cloistered little world of lab values that none of them have ever heard of a ketogenic diet, and how that diet alone gives similar results? Yes, if you eat too much fat and overall calories on keto, you can fail to lose weight, and if you go completely overboard on fats and cals on keto, you could even gain weight - but generally speaking, you aren't likely to gain nearly as much weight on an equivalent number of calories on keto as you would on SAD. It's not just a calorie game, it's how the human body (as opposed to a mouse body) uses those calories.
But that's not important in the lab! Oh, no - what's important is figuring out some new drug or food additive they can sell so people can continue eating whatever junk they want,
while not gaining as much weight as expected. My guess is that when they market the MSPs, they'll still be combined with a low fat diet, which by the way is not even what the gave the mice, so I hate to think about the results of that -take a nutritionally poor diet, block part of the calorie absorption (and very likely a good bit of the nutrient absorption), and even if their metabolisms improve a bit, they'll be even worse off in the end.