Tue, Jun-01-10, 16:36
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Experimenter
Posts: 25,861
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Plan: DDF
Stats: 202/185.4/179
BF:
Progress: 72%
Location: San Diego, CA
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2010 A disappointing year for statinators
http://www.jstage.jst.go.jp/article/jln/19/1/65/_pdf
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Quote:
ABSTRACT
The cholesterol-lowering drug trials published in 2008-2009 were either negative
(ENHANCE, SEAS, GISSI-HF, AURORA) or obviously biased and therefore not credible
(JUPITER). How can we explain this wave of negative cholesterol-lowering drug trials? In
this article, authors review and comment the results of these recent trials. It is also
noteworthy that most cholesterol-lowering drug trials published between 2005 (the year
of the Vioxx affair and of enforcement of new clinical trial regulations) and 2007 were also
negative or ambiguous. Taken together, these recent trials, including those of 2008-2009,
strongly suggest that the results of previous, highly positive trials with statins —
particularly in the secondary prevention of coronary heart disease — published between
1994 and 2004 and that were used to issue guidelines for medical practitioners should
be carefully re-examined by experts independent from the pharmaceutical industry. The
next question would be whether it is not time for a full reappraisal of the theory according
to which cholesterol-lowering results in a significant protection against cardiovascular
morbidity and mortality.
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Last edited by Nancy LC : Tue, Jun-01-10 at 16:43.
Reason: Bizarre typo in the title
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