Study: New drug boost levels of heart-healthy good cholesterol

10:01 AM CDT on Thursday, April 8, 2004

Associated Press

http://www.dallasnews.com/sharedcon....105b7e8b1.html

The good cholesterol HDL, which reduces the risks of heart disease, can be dramatically boosted by an experimental drug that also lowers bad cholesterol, according to a preliminary study.

Potentially offering an entirely new way to prevent heart attacks, researchers at University of Pennsylvania and Tufts University found that the drug doubled HDL in people with worrisomely low levels of the heart-healthy substance. The drug, called torcetrapib, also reduced LDL, the bad cholesterol.

Good cholesterol reduces the risk of heart disease; bad cholesterol raises it.

Until now, doctors have concentrated largely on lowering bad cholesterol by giving patients statin drugs, which are used by millions of Americans and reduce heart attacks by about one-third. Many experts hope to drive down heart disease still further by boosting good cholesterol, too, and several strategies are in testing.

The latest study was small, involving just 19 patients, but its striking results suggest torcetrapib can have a powerful effect.

The drug is still a few years away from reaching the market. The next step will be to test its safety and effectiveness in much larger numbers of volunteers and show whether the higher HDL truly results in fewer heart attacks and strokes.

"One of the big questions that we do have with this drug is: Will using it to raise HDL levels from normal to high actually reduce risk in people who are at high risk?" said the study's senior author, Dr. Daniel Rader, Penn's director of preventive cardiovascular medicine.

Ultimately, the drug could be used in combination with statins to simultaneously lower a patient's bad cholesterol and boost good cholesterol.

The study, paid for in part by Pfizer Inc., torcetrapib's maker, was published in Thursday's New England Journal of Medicine.

Currently, the only HDL raiser in the market is the vitamin niacin, but its effects are modest and side effects such as itching and hot flashes bother many patients.

Whether torcetrapib will prove to be the first potent prescription drug in this category will require much more study, but some researchers said they were impressed by the initial results.

"I'm convinced that it works," said Dr. Norman Lasser, director of preventive cardiology at the University of Medicine and Dentistry of New Jersey in Newark.

In the next stages of testing, patients will have to be followed for several years to spot any side effects and prove the cholesterol changes result in fewer heart attacks for people with risk factors such as obesity, diabetes, smoking and lack of exercise.

"We're three to five years away from showing that," said Dr. Richard A. Stein, an American Heart Association spokesman and chief of the medical service at Beth Israel Medical Center's Singer Division in New York.

LDL particles -- clusters of cholesterol molecules surrounded by proteins -- act like big boats, transporting cholesterol from the liver and depositing it in blood vessels, where it can cause deadly clogs. In contrast, HDL particles pick up cholesterol in the blood vessels and shuttle it back to the liver for excretion.

Torcetrapib blocks the activity of a protein that acts like a ferry to transfer cholesterol from the HDL boat into the LDL boat. As a result, HDL levels rise and LDL levels fall.

The 19 patients took a 120-milligram torcetrapib pill daily for four weeks; 10 also took the statin Lipitor every day.

HDL levels rose an average of 46 percent in those taking just torcetrapib, to 46 milligrams per deciliter, and jumped 61 percent, to 47, in those getting both medicines. Six patients took the torcetrapib pill twice a day in the study's third phase, and their HDL jumped 106 percent, to 70.

In the United States, men's average HDL is about 45 and women's is 55. HDL under 40 is an especially bad sign, while anything over 60 is considered good. Studies suggest that each single point of increase in HDL is matched by a 2 percent to 3 percent reduction in heart disease.

The researchers noted that torcetrapib reduced blood levels of another fat that contributes to heart disease, triglycerides, by about 20 percent. The drug reduced LDL cholesterol 8 percent when used alone, and 17 percent when taken twice daily or once a day in combination with Lipitor.

Dr. H. Bryan Brewer Jr. of the National Heart, Lung, and Blood Institute wrote in an accompanying editorial that torcetrapib and similar drugs now being tested "hold great promise as a new class of drugs that will be of major benefit" in treating patients who have heart disease or are in danger of developing it.