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Old Thu, Feb-21-19, 15:39
nawchem's Avatar
nawchem nawchem is offline
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Default Muscle memory discovery ends 'use it or lose it' dogma

Lawrence M. Schwartz. Skeletal Muscles Do Not Undergo Apoptosis During Either Atrophy or Programmed Cell Death-Revisiting the Myonuclear Domain Hypothesis. Frontiers in Physiology, 2019; 9 DOI: 10.3389/fphys.2018.01887

The old adage "use it or lose it" tells us: if you stop using your muscles, they'll shrink. Until recently, scientists thought this meant that nuclei -- the cell control centers that build and maintain muscle fibers -- are also lost to sloth.

But according to a review published in Frontiers in Physiology, modern lab techniques now allow us to see that nuclei gained during training persist even when muscle cells shrink due to disuse or start to break down. These residual 'myonuclei' allow more and faster growth when muscles are retrained -- suggesting that we can "bank" muscle growth potential in our teens to prevent frailty in old age. It also suggests that athletes who cheat and grow their muscles with steroids may go undetected.

Our biggest cells are in our muscles, and they're all fused together

Syncytium. Sounds like a neo-noir comic book series. It's actually a special type of tissue in your body, where cells are fused together extra close -- so close, that they behave a like a giant single cell.

"Heart, bone and even placenta are built on these networks of cells," says Lawrence Schwartz, Professor of Biology at the University of Massachusetts. "But by far our biggest cells -- and biggest syncytia -- are our muscles." Like the Sin City series, it appeared at first that everything was black and white with syncytia.

"Muscle growth is accompanied by the addition of new nuclei from stem cells to help meet the enhanced synthetic demands of larger muscle cells," explains Schwartz. "This led to the assumption that a given nucleus controls a defined volume of cytoplasm -- so that when a muscle shrinks or 'atrophies' due to disuse or disease, the number of myonuclei decreases."

A muscle can gain nuclei, but never loses them

This assumption long seemed valid, with many researchers reporting the presence of disintegrating nuclei in muscle tissue during atrophy induced by inactivity, injury or paralysis. But modern cell-type-specific dyes and genetic markers have shown that the dying nuclei other researchers had detected were in fact inflammatory and other cells recruited to atrophic muscle.

The new evidence paints a very different picture of muscle syncytium.
"Use it or lose it -- until you use it again"

Since myonuclei are the synthetic engine of muscle fibers, retaining them should enable muscle size and strength to recover more quickly after one of these insults, and help to explain the phenomenon of 'muscle memory'.

"It is well documented in the field of exercise physiology that it is far easier to reacquire a certain level of muscle fitness through exercise than it was to achieve it the first place, even if there has been a long intervening period of detraining. In other word, the phrase "use it or lose it" is might be more accurately articulated as 'use it or lose it, until you work at it again'."

As such, the findings have important implications beyond understanding muscle biology.

"Informing public health policy, the discovery that myonuclei are retained indefinitely emphasizes the importance of exercise in early life. During adolescence muscle growth is enhanced by hormones, nutrition and a robust pool of stem cells, making it an ideal period for individuals to "bank" myonuclei that could be drawn upon to remain active in old age."
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