Werebear, if it can help, I wanted to figure out why niacin provides benefits. I think I found something. Niacin is antifungal.
https://www.sciencedaily.com/releas...00708141617.htm
It may or may not be pertinent to you personally, but I see how niacin can be used as a diagnostic tool. If there is a fungal infection, niacin will have a specific effect. If there is no fungal infection, niacin will have a different specific effect. Based on the effect, we can determine if there is a fungal infection.
A fungal infection can cause various symptoms depending on the specific tissue infected. For example, skin = rash/lesions/etc, or stomach = acid reflux/indigestion/etc. I want to avoid projecting my own experience to yours, but I think that you and I have a common problem - the liver is somehow affected by some disorder of some kind. In my case, it's obvious to me that if my liver is affected by a disorder, it's affected by the same disorder that affects other tissues on my body, including my skin where there's several patches of obvious infection, most likely some fungus, even more likely candida. If my liver is infected (by candida or something else), everything is wrong, because the liver controls everything, especially the various hormones that regulate energy supply. If energy supply is disrupted at its foundation, other hormones take over to compensate, i.e. cortisol and epinephrine for example, both of which also cause stress and anxiety especially when chronically elevated. In turn, other systems become disrupted indirectly through various means, such as lack of sleep that will interfere with growth hormone for example, which is otherwise essential for good health.
OK, enough of me. The point is niacin is antifungal and can be used as a diagnostic tool specifically to determine if there is a fungal infection. I don't know if niacin can be used on its own to treat a fungal infection. If it can, then it should treat it and whatever symptoms there were should disappear along with the fungus. How long that would take, I don't know. The point here is that the effect of niacin should now be different because there is no longer an infection. Again, based on the effect, we can determine if the infection has been treated.
I'm just saying, it's something to investigate.