Sun, Jan-27-13, 09:53
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Experimenter
Posts: 25,866
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Plan: DDF
Stats: 202/185.4/179
BF:
Progress: 72%
Location: San Diego, CA
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Why Mom & Dad or Grandma and Grandpa were thin, and you're not.
Possible explanation here:
New Suite of Chemicals May Cause Disease Generations Later: Plastics and Jet Fuel Raise Incidence of 'Epigenetic Transgenerational Inheritance
Epigenetics in a nutshell:
Genes are a blueprint of how the body operates that are passed down from your parents to you. It isn't destiny that if you have a particular gene you'll have a disease, however if you have two copies of a certain gene you'll be much more likely to have that disease (or trait) and sometimes you are guaranteed to have it, it just depends. Genes are potential traits.
There's an environmental component to it too. On top of the genetic structure is another layer that's relatively newly discovered called the "epigenome". This influences the genome and activates or disables genes.
Over a lifetime, identical twins become less and less identical. At the gene level, they're still identical, but at the epigenetic level they begin to diverge at birth.
Nova has a wonderful program on epigetics
Anyway, apparently they are starting to see how epigenetics works and how the epigenome can be passed down to offspring from the parents.
So, the title I posted this as gives us a possible explanation for the obesity epidemic. Things which began becoming commonplace in the 1950's and after start to enter the environment. Mom's begin acquiring epigenetic changes. Those changes might not affect the Mom herself, but her offspring.
Quote:
"Your great-grandmothers exposures during pregnancy may cause disease in you, while you had no exposure," he said. "This is a non-genetic form of inheritance not involving DNA sequence, but environmental impacts on DNA chemical modifications. This is the first set of studies to show the epigenetic transgenerational inheritance of disease such as obesity, which suggests ancestral exposures may be a component of the disease development."
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