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  #1   ^
Old Fri, Jul-30-10, 16:45
amergin's Avatar
amergin amergin is offline
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Default "Calcium pills 'increase' risk of heart attack" BBC

BBC website 30/7/2010

http://www.bbc.co.uk/news/health-10805062

Calcium pills 'increase' risk of heart attack
By Emma Wilkinson Health reporter, BBC News
Calcium pills Calcium supplements are commonly taken by older people at risk of fracture

Calcium supplements taken by many older people could be increasing their risk of a heart attack, research shows.

The study, in the British Medical Journal, said people who took supplements were 30% more likely to have a heart attack.

Data from 11 trials also suggested the medicines were not very effective at preventing bone fractures.

Almost 3m people in the UK are thought to have osteoporosis and many take calcium pills to prevent fractures.

The study recommends doctors review their use of calcium supplements for managing osteoporosis.

The National Osteoporosis Society said most people should be able to get enough calcium through their diets, rather than reaching for the medicine cabinet.

The researchers said those who had a diet naturally high in calcium were at no increased danger.
'Limited benefit'

In all 12,000 people aged over 40 took part in the trials of calcium supplements of 500mg or more a day.

“It is a balance of risks - people should consider the risks involved and how they apply to their own circumstances and discuss the matter with their GP" Dr Alison Avenell Study author

The risk of heart attack was seen across men and women, was independent of age and the type of supplement given.

A small increased risk of death was seen in the study but was not statistically significant, the researchers said.

The reason for the increased risk of heart attack is not clear but it is thought the extra calcium circulating in the blood could lead to a hardening of the arteries.

Calcium in the diet is safe and the Food Standards Agency recommends adults have 700mg of calcium a day from milk, cheese and green, leafy vegetables.

Dr Alison Avenell, from the University of Aberdeen which did the research with colleagues in New Zealand and the US, said the evidence suggests calcium supplements only have a limited benefit in preventing fractures, especially when compared to other treatments available.

"It is a balance of risks - people should consider the risks involved and how they apply to their own circumstances and discuss the matter with their GP," she said.

She added the results did not necessarily apply to younger people with conditions for which they take calcium.

Judy O'Sullivan, senior cardiac nurse at the British Heart Foundation, said the results should be interpreted with caution because the trials did not set out to look at the risk of heart attack.

"However, the research should not be completely ignored," she said.

"Any new guidelines on the prevention of fractures in those most vulnerable to them should take this type of analysis into account."

Dr Claire Bowring, of the National Osteoporosis Society, said: "We've always recommended that people should aim to get the calcium they need from their diet to help build stronger bones.

"If you get all of the calcium that you need from your diet and adequate vitamin D from exposure to sunshine, then a supplement will not be necessary."

She said there were still questions to be answered about the treatment of osteoporosis but advised people taking calcium supplements to talk to their GP, especially if they have a heart condition.
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  #2   ^
Old Sun, Aug-01-10, 10:12
Didy's Avatar
Didy Didy is offline
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Good to know. Thanks for posting!
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  #3   ^
Old Mon, Aug-02-10, 07:50
renegadiab renegadiab is offline
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Plan: Schwarzbein/Bernstein
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Bone problems may have more to do with lack of fat to help adsorb calcium and low vitamin D levels than with "inadequate" calcium intake.
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  #4   ^
Old Mon, Aug-02-10, 08:17
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Hutchinson Hutchinson is offline
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Here is another reasonable summary of the story.
Calcium linked to higher risk of heart attacks BMJ Group

Dr Davis Heartscanblog has been warning about too much supplemental calcium for some time. He specializes in reducing calcification by using scans to monitor the effect of his dietary and lifestyle modifications and uses EFFECTIVE strength D3 supplements so has first hand knowledge of the need (or lack of) calcium when 25(OH)D levels are above 40ng/ml.

this paper shows that
Dietary calcium and serum 25-hydroxyvitamin D status in relation to BMD among U.S. adults. Above vitamin D Levels of > 20 ng/ml Men don't need more than 626 mg/day supplemental calcium, and women with D don't need more than 566 mg/day.

If you raise your 25(OH)D to around or above 40ng it's possible you will absorb even more calcium from food/water and thus be able to reduce supplemental calcium even more.

Magnesium counterbalances the actions of calcium so it's important to ensure you are getting sufficient magnesium anyway and particularly if you use calcium supplements. See what Krispin says here It is more likely you are deficient in magnesium than calcium as food/water sources of calcium are more readily available but modern crop varieties have reduced magnesium content.

Vitamin K2 also helps to lock calcium into bones and checking the acidity of your urine

reducing the acidogenicity of the diet into the alkali-producing range with bicarbonate lowers calcium excretion and the bone resorption rate in healthy older men and women consuming rather typical acid-producing American diets.

Recipe for Magnesium Bicarbonate water

For UK readers the cheapo discount retailer Aldi do a carbonated spring water £1 for 4 x 2lt with a high magnesium bicarbonate level, for those without access to a soda stream.

remember
-Adults under age 50 need a total of 1,000 mg of calcium from all sources every day.

-Adults 50 and older need a total of 1,200 mg of calcium from all sources every day. and the
BEST source is diet = food and water

We should be getting MOST of our calcium from FOOD and WATER,

It's not that difficult to ring your local water provider or check their internet based information or read the label on your bottled water, then do the sums based on your total daily water consumption.

Same with food sources, it may take a bit of time to work out roughly how much yoghurt, cheese, milk fish greens etc. you average daily over the week but it's fairly straightforward.

Milk & yogurt 8 oz 300-450 mg
Cheese 3 oz 300-450 mg
Bones in canned sardines and salmon 3 oz 181-325 mg
Calcium fortified foods (i.e., orange juice, soy milk) 8 oz 200-300mg
Dark green, leafy vegetables 1 cup 100-200 mg

It's then just basic math to add those figures together and subtract from 1200mg/daily to work out how much calcium you need to supplement with.
If the difference between what you are getting from diet and need to supplement with is more than 500mg then it's a matter of seeing how you can improve you dietary intake so you are not needing to take 500mg or more daily.
Remember also that Calcium Carbonate is the supplement form MOST likely associated with problems and the least likely to cause problems is Calcium Citrate/Malate blends code ~~~~~~ $5 introductory discount Looks like they may be cheaper from Vitaminlife if you can't use the discount code (depending on shipping cost) remember no one should be taking the recommended serving size because you should ALL be getting the greatest amount of calcium from your food/water, and the supplement should only be to make up any shortfall.
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  #5   ^
Old Wed, Aug-04-10, 22:33
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Atrsy Atrsy is offline
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I was watching Dr. Rosenthal on TV and he was talking about a study to determine if calcium supplements in older women caused plaque in the arteries. What they found was that the extra calcium in post menopausal women went directly to their bones and not to the arteries. They didn't say anything about men. Somehow, this seemed linked to the decrease in estrogen during menopause.
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  #6   ^
Old Thu, Aug-05-10, 03:15
Hutchinson's Avatar
Hutchinson Hutchinson is offline
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Plan: Dr Dahlqvist's
Stats: 205/152/160 Male 69
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Quote:
Originally Posted by Atrsy
What they found was that the extra calcium in post menopausal women went directly to their bones and not to the arteries.
Without a link to the actual study he was referring to it's difficult to comment except to point out that the latest understanding comes from a META analysis, which combines the results from several papers.

Given it's not that difficult to ensure you provide sufficient calcium in your diet, and it's not that difficult or expensive to correct vitamin D insufficiency to raise 25(OH)D to above 40ng/ml 100nmol/l so you are able to maximise the uptake of that calcium, and it's pretty easy to reduce the acidic nature or your diet so you reduce calcium loss in your urine, it seems to me Calcium supplements are unnecessary and given their uncertain benefits, any level of increased heart attack risk is unwarranted.
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  #7   ^
Old Thu, Apr-21-11, 01:26
Pilili Pilili is offline
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Default New analysis slams calcium supplements over heart problems

New analysis slams calcium supplements over heart problems

Quote:
By Nathan Gray, 20-Apr-2011

Related topics: Research, Minerals, Vitamins & premixes, Bone & joint health, Cardiovascular health

Researchers have warned that the indiscriminate use of calcium supplements ‘should be abandoned’, as a meta-analysis of 29,000 people suggests the risks of heart problems outweigh the potential benefits.

The new data, published in the British Medical Journal, suggests that calcium supplements – when taken with, or without vitamin D – may increase the risk of heart attack by 25 per cent, and the risk of stroke by 15 per cent. The new findings back up the results of an earlier meta-analysis that suggested calcium supplementation could have more risks than benefits .

Professor Ian Reid, senior author of the study, told NutraIngredients that the new data provides “a significant body of evidence that says there is a concern.”

“When we do the calculations from these 29,000 people, we find that for every thousand people we give calcium to for five years, we cause six heart attacks and we prevent three fractures,” said Reid.

“The message from last years study, to this years study is very consistent, and that is that it’s not a very effective way of preventing fractures, and it probably does carry a significant risk,” he warned.

Previous research

Last year, Professor Reid and his researcher team published a study suggesting that regularly supplementation with calcium to reduce the risk of osteoporosis may cause more heart attacks than the number of fractures they prevent.

The previous study (reported here ) looked at calcium supplementation alone, however many people take calcium combined with vitamin D, so Reid and his team then set out to see if their findings held true when this was taken into account.

Study details

Prof. Reid said that the new research was “not so much a re-analysis”, but a new study, which includes a re-analysis.

“What we have done is now found three studies which have calcium plus vitamin D as the intervention … that’s another 17,000 new people in which we looked at the incidence of heart attacks and strokes,” he explained

The results of studying these 17,000 people showed “exactly the same increase in risk from this as we found before” said Reid. “So then we went ahead and combined this data with the data from last year’s meta-analysis of 12,000 people to give us a total meta-analysis of 29,000 people,”

From this overall data, the researchers found a 25 per cent increase in the risk of heart attack, and a 15 per cent increase in the risk of stroke.

“Those effects are much the same as we found last year in terms of the risk size, but now because we have a much larger pool of people, the differences in the data have much higher statistical significance,” said Reid.

“We have a very consistent pattern … you find that in the major studies heart attack risk is very consistent, irrespective of whether or not they are taking vitamin D with the calcium,” concluded Reid.

Industry action

The research team are now investigating the mechanisms behind the effects of calcium supplementation to try and understand why taking supplements may pose a risk to heart health, whilst consuming calcium rich food does not.

Reid told NutraIngredients that finding the mechanisms behind the potential increased risk opens up the possibility of designing calcium supplements that are safer to use.

He confirmed that they are currently working with industry, “to look at ways or means of creating a safer way to deliver calcium to people,” adding that research team is happy to work more with industry “to look into these issues and try to come up with solutions.”

Prof. Reid warned that supplement manufacturers must pay attention to the risks as well as the benefits of calcium supplementation, adding that ignoring or dismissing the issue is not a suitable answer.

“The forms of supplements we are using at the minute are measurably not safe, and I think that if industry ignores that fact, or refuses to engage, it may be opening itself up to liability in the future,” he warned.

Close scrutiny

Industry groups have been quick to react to the study; John Hathcock, senior vice president of scientific and international affairs at the Council for Responsible Nutrition (CRN) told NutraIngredients that he “wouldn’t put a lot of weight” on the conclusions, adding that he believed the methodology of the study “raises more questions than it provides answers.”

“Instead of considering these findings a coincidence or a statistical abnormality as there are with many analyses of large pools of data with many variables, the authors instead suggest that the abrupt change in blood calcium levels after supplementation is what causes the effect … It seems more likely that findings are a procedural or statistical anomaly,” said Hathcock

Reid responded by adding that he knew the research findings would be “a high stake statement.” He said the “net losers would of course be industry […] because it has substantial impact on all the people who take calcium and also on all the people who make it.”

“For that reason we have been expecting very close scrutiny and I think we have been particularly meticulous in the way we carried out this analysis so that any scrutiny doesn’t hold problems for us,” he said.

Source: British Medical Journal
Published online ahead of print, doi:10.1136/bmj.d204
“Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis”
Authors: M.J. Bolland, A. Grey, A. Avenell, G.D. Gamble, I.R. Reid
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  #8   ^
Old Thu, Apr-21-11, 10:03
Nancy LC's Avatar
Nancy LC Nancy LC is offline
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Yeah, I stopped taking calcium awhile back based on what Dr. Davis was blogging about this. Or actually, I stopped feeling guilty I was so irregular about taking my calcium supplements...
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