Mon, Oct-30-17, 12:38
I was just checking out Amazon to see how popular these products were. They do appear to be quite hot right now. I found a thoughtful review of THIS PRODUCT
. This reviewer seemed to know much more about the subject than I. Here is his review...
Top customer reviews
1.0 out of 5 stars
More Harm than Good
By J. Robertson July 22, 2017
Package Quantity: 5
First, the good: Tastes decent.
Now, the main reason I wanted to review this is that Pruvit and other ketone manufacturers are pulling the wool over your heads by conflating research on ketosis with taking ketones, which is completely different due to the difference in biochemical pathways of exogenous ketones verses endogenous ketones produced by being in a natural ketonic state. The data behind dietary ketosis is very good, but I didn’t like what I saw in the data regarding exogenous ketones. While naturally induced ketosis does cause an increase in fat used for fuel (due to the absence of dietary fuel – think carbs/glucose - needed to enter a state of ketosis), the data on exogenous ketone consumption (such as taking KetoOS) shows consistently that taking in exogenous ketones actually *halts* lipolysis and causes circulating glucose and fatty acids to be stored until the exogenous ketones have been used up as fuel. The exogenous ketones did have a benefit of mildly increasing energy and slightly increasing cognitive function due to the more immediate availability of fuel for the brain, but the negative feedback on lipolysis and suppression of hepatic glycogen use was disappointing. Also, one thing that alarmed me quite a bit more was that exogenous ketones caused a nearly doubled increase in blood insulin levels, because with the presence of exogenous ketones, the body has to facilitate the clearance of the circulating glucose not being used as fuel by sharply increasing insulin. That could be good or bad, depending on one’s goals I suppose: On one hand, insulin is very anabolic and could contribute to muscle gains, on the other, excessive blood insulin can lead to insulin resistance and fat storage, and potentially type 2 diabetes. That's terrible.
I think if a person wants to try exogenous ketones such as KetoOS, they should only do so on a severely carb restricted diet, so as not to risk the fatty acid storage and glucose uptake via the significantly increased insulin in the blood. I think if paired with a low carb diet, it could possibly help provide the needed endurance for a workout (due to the ATP increase from the ketones) without halting lipolysis in between (since on a low carb diet one wouldn’t be consuming much glucose or having much glucose conversion). For my type of workouts (80% lifting, 20% crossfit style), I’m relying more on the glycogen cycle and carb cycling, which already manipulate an intermittent natural ketotic state, and adding exogenous ketones would throw that off, suppress hepatic glycogen use, increase glycation, and result in the insulin spikes. Again, bad news.
On a positive note, there are good data showing that people with degenerative neurological conditions might benefit greatly from exogenous ketones. That’s something I hope they keep studying and maybe THAT's where exogenous ketones have a valid application.
I would recommend not boarding the ketone train. The studies I’ve seen (which is a pretty good bit) that ketone manufacturers regularly cite and footnote are not regarding exogenous ketones, but rather natural ketosis from dietary restriction, and that’s very, very different. I actually wrote to one company some years ago asking why they were using studies on dietary induced ketosis to support their ketone product when the biochemical pathways and metabolic processes were entirely different, with different resulting biproducts and consequences – unfortunately, he blew me off and got mad, so I never got an answer. When a company misuses scientific research and conflates something as different as nutritional ketosis with taking exogenous ketones, that should be a huge red flag.
You should approach stuff like that with extreme caution, especially when seeing those studies for one thing (exogenous ketones) equivocated to a similar thing (natural ketosis) that is in fact, not the same. In the meantime, perhaps exogenous ketones could be beneficial for anyone wanting a good secondary source of energy for “clean fuel” while on a ketogenic or low-carb diet, or for energy during endurance training that could make good use of the increase in ATP, or of course, for anyone suffering from a degenerative neurological disorder since there seems to be a lot of promise there in the data. What would be nice, is if one of the ketone companies, instead of using unrelated nutritional ketosis research, just said, “Hey, we’re going to prove our product. We’re doing a double-blind placebo controlled study using our product to produce data showing effects of taking it on various metabolic …” yada, yada, yada. Don't hold your breath though - as long as people hashtag #ItsScience there are masses who will just eat it up without researching.
On the Pruvit website, they have a video for their KetoOS product. It’s actually a pretty good primer video for explaining ketosis in general. My problem with it, is that toward the end it claims taking exogenous ketones will put a person into nutritional ketosis. But that’s not true at all according to the science. Nutritional ketosis is only achieved through nutritional deprivation of carbs/sugars, which then cause the body to enter true ketosis, producing its own ketone bodies. Taking in exogenous ketones simulates a pseudo-ketosis, but without the severe carb restriction, causing a cascade of metabolic events (like I described before) that halt lipolysis, rather than facilitate it.
Essentially, a person in true (nutritional) ketosis, has used the circulating carb/glucose and energy stores, so once they then burn through hepatic glycogen they’ll then enter nutritional ketosis and burn fat for energy. That’s the huge benefit of true ketosis. However, because ketones are a more readily available energy source, when a person takes exogenous ketones without sugar/carb deprivation, the body will use the ketones for energy first while storing the fatty acids and glucose energy (carbs/sugars) in two places: as glycogen in the liver, and as fatty acids in fat cells. Also, once the blood concentration of ketone bodies exceeds 1mg/dl, the excess is simply peed out unused, known as ketonuria (the ketone companies very slickly suggest urine tests for ketones to "prove you're in ketosis" - that's BS, you're just peeing it out). So, giving the body a continuous supply of exogenous ketones that it did not have to expend any energy to produce, means that the body never has to burn the glucose/glycogen or fat for energy – it simply awaits its next free ketone feeding and continues to store the other stuff for “harder times” when easy, no-cost energy isn’t readily available, and pees out the ketones it didn’t use. Meanwhile, while the circulating glucose is not used, since there’s a free supply of ketones at no metabolic cost, the body releases large amounts of insulin to clear the circulating carbs/glucose still being consumed but not burned, resulting in potential insulin resistance. This is why the best use for exogenous ketones is only with a severe carb restricted diet (literally less than 50gm/day), or prior to some tough endurance activity requiring extra energy.
To use the same campfire analogy from the video, ketones would represent drier lint; a quickly burned, readily available fuel source. If you keep throwing lots of drier lint on the fire, it never needs to burn deeper down into the logs (protein) or coal (fat), since drier lint (ketones) is being constantly thrown onto the fire for fuel. And if you keep adding kindling (carbs) to the fire, while also putting drier lint (ketones) on it, the fire will just about never get down to burning the logs (protein) and coal (fat) – at least, it would take a very, very long time.
That’s one of the reasons I get a little frustrated at supplement companies, and videos like that, that produce genuinely good information on something like legitimate nutritional ketosis, and then deceive people by saying their product accomplishes the same, when it doesn’t. If consumers aren’t told the truth, it can hurt them. A person following an ultra low-carb or a ketogenic diet, would probably be fine taking exogenous ketones and might benefit, but someone who takes them while eating “normal” (especially someone with excess adipose tissue) is placing themselves in danger of causing excess glycation, fatty liver, insulin resistance, and even type 2 diabetes. So it irks me when they pretend like exogenous is the same as endogenous to sell something. But it’s not just ketones – much of the supplement world uses deceptive advertising and misuses research, knowing that the average Joe isn’t going to read the long, boring, highly technical studies. I think if Pruvit would’ve left off the false equivocation of exogenous ketone consumption with actual nutritional ketosis, it would’ve been an excellent video on the benefits of achieving a state of ketosis. I think a more honest presentation of who the product benefits (people on low-carb/ketogenic diets, endurance athletes, and people with degenerative neurological disorders), verses people who *shouldn’t* take the product (people who eat normal, carb cycle, or who have excess adipose tissue), would go a long way in showing the company’s integrity and commitment to honest advertising. I just want companies who sell them to not misuse scientific research, conflating unrelated processes, and to look out for us consumers and be honest with who should and shouldn’t take a given product. I think one of the most important things Pruvit (and other ketone companies) should market at this point, is threefold: 1) Be clear that ketone products should *not* be taken unless on a very low-carb or ketogenic diet, 2) Be very up front about the negative metabolic consequences of taking exogenous ketones without simultaneous severe carb restriction, and 3) Make sure to stop conflating true nutritional ketosis with effects of exogenous ketone consumption.