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  #1   ^
Old Wed, Feb-01-23, 18:11
Dodger's Avatar
Dodger Dodger is offline
Posts: 8,758
 
Plan: Paleoish/Keto
Stats: 225/167/175 Male 71.5 inches
BF:18%
Progress: 116%
Location: Longmont, Colorado
Default What Happens When Patients Stop Weight-Loss Medications?

Quote:
Semaglutide, like other medications that are used for obesity treatment, have to be taken long term. Just as for any other chronic disease, if a medication is stopped for any reason, the disease is no longer being treated. So, for example, if somebody is taking a medication for hypertension, if you stop that anti-hypertensive medication, the blood pressure goes up and we're not surprised.

In the same way, if someone is taking a medication for obesity treatment, when it is stopped, weight gain occurs -- or weight regain occurs, more accurately.


https://www.medpagetoday.com/endocr.../obesity/102894
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  #2   ^
Old Thu, Feb-02-23, 07:54
GRB5111's Avatar
GRB5111 GRB5111 is offline
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Posts: 4,036
 
Plan: Very LC, Higher Protein
Stats: 227/186/185 Male 6' 0"
BF:
Progress: 98%
Location: Herndon, VA
Default

The rebound effect. Wonder who this benefits when it's identified as a "lifelong" medication?
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  #3   ^
Old Thu, Feb-02-23, 09:24
doreen T's Avatar
doreen T doreen T is offline
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Plan: LC paleo/ancestral
Stats: 241/188/140 Female 165 cm
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Progress: 52%
Location: Eastern ON, Canada
Default

Quote:
Originally Posted by GRB5111
Wonder who this benefits when it's identified as a "lifelong" medication?

Drug company CEO's and shareholders?
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  #4   ^
Old Thu, Feb-02-23, 09:46
GRB5111's Avatar
GRB5111 GRB5111 is offline
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Posts: 4,036
 
Plan: Very LC, Higher Protein
Stats: 227/186/185 Male 6' 0"
BF:
Progress: 98%
Location: Herndon, VA
Default

Quote:
Originally Posted by doreen T
Drug company CEO's and shareholders?

Exactly, they're never invested in curing or resolving, so "lifelong" enables them to continue to print money.
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  #5   ^
Old Fri, Feb-10-23, 05:07
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JEY100 JEY100 is online now
Posts: 13,371
 
Plan: P:E/DDF
Stats: 225/150/169 Female 5' 9"
BF:45%/28%/25%
Progress: 134%
Location: NC
Default

Marty Kendall added a new article today on Weight Loss drugs. It was not as positive as he hoped but has comments at the end from members of the Optimising Nutrition community who have been able to use them successfully in conjunction with nutrient dense foods.

Weight Loss Drugs: Does Satiety Now Come in a Needle?
https://optimisingnutrition.com/wei...dle/#more-39405

Quote:
These new drugs could be life-changing for the many who desperately need to lose weight for their health, especially if they are able to build new habits and optimise their nutrition.

In this article, we’ll look at:

How these new drugs work,
Why they are prescribed for people with Type 2 Diabetes,
The risks and the cost,
How much weight can you lose, and what are the chances of gaining it back when you stop?
How GLP-1 works in your body, and
How you can increase GLP-1 naturally.
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  #6   ^
Old Fri, Feb-10-23, 05:24
WereBear's Avatar
WereBear WereBear is offline
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Posts: 14,608
 
Plan: EpiPaleo/Primal/LowOx
Stats: 220/125/150 Female 67
BF:
Progress: 136%
Location: USA
Default

Endocrinology stopped in the 1920s I swear.

I could write an app that could replace them now, they are so mechanistic.

That's what my husband calls the process of a doctor who doesn't even see the patient. The hand is writing prescriptions instead.
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  #7   ^
Old Fri, Feb-10-23, 08:51
WereBear's Avatar
WereBear WereBear is offline
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Posts: 14,608
 
Plan: EpiPaleo/Primal/LowOx
Stats: 220/125/150 Female 67
BF:
Progress: 136%
Location: USA
Default

I totally believe that these folks could continue to have problems and need endocrine support. Their progress, as described in the article JEY linked, shows that hormones balance with the proper nutrition.

That's what I've been betting on during my autoimmune recovery. I'm trying to fix insulin, cortisol, cortisol resistance, thyroid, neurohormones like niacin, and protein for lots of raw neurotransmitter power.

Interventions can be beneficial. I'd like to see drugs go back to actually curing or at least helping instead of today's cascade of side effects to no real purpose.
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  #8   ^
Old Fri, Feb-10-23, 13:46
deirdra's Avatar
deirdra deirdra is offline
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Posts: 4,324
 
Plan: vLC/GF,CF,SF
Stats: 197/136/150 Female 66 inches
BF:
Progress: 130%
Location: Alberta
Default

The drug may curb their hunger and they may lose weight, but the fact that they gain it all back would indicate that they are eating the same old crap, just less of it while on the drug. To improve their HEALTH, they need to eat nutritious real food, which will satiate them at no extra cost, and learn to eat properly for life.
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  #9   ^
Old Sat, Feb-11-23, 09:05
GRB5111's Avatar
GRB5111 GRB5111 is offline
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Posts: 4,036
 
Plan: Very LC, Higher Protein
Stats: 227/186/185 Male 6' 0"
BF:
Progress: 98%
Location: Herndon, VA
Default

Even more cynical are those who are well off and not obese and/or don't have health risks due to weight and are taking this class of drugs to stay slim, for vanity. Also, I hear these drugs are very expensive with initial subsidies available to patients in need that won't last more than a few years let alone a lifetime. After researching and reading about behind-the-scenes actions of the pharmaceutical industry and drug approvals, my suspicions automatically ramp up nowadays with any newly approved drug. Especially when the pharmaceuticals are not required to share the adverse event data from their RCTs.
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  #10   ^
Old Sat, Feb-11-23, 14:05
WereBear's Avatar
WereBear WereBear is offline
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Posts: 14,608
 
Plan: EpiPaleo/Primal/LowOx
Stats: 220/125/150 Female 67
BF:
Progress: 136%
Location: USA
Default

I've also been finding out that they do extremely low numbers of people in these tests, considering they then unleash it on a nation.
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