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  #1   ^
Old Sat, Mar-25-23, 01:21
Demi's Avatar
Demi Demi is offline
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Plan: Muscle Centric
Stats: 238/153/160 Female 5'10"
BF:
Progress: 109%
Location: UK
Default We may finally know why people tend to regain weight after losing it

Quote:
We may finally know why people tend to regain weight after losing it

When mice lose weight, brain signals that trigger hunger are dialed up, making the animals eat more until they return to their starting weight


Researchers have identified a brain pathway in mice that may explain why people tend to regain lost weight. Future therapies targeting this pathway could help with weight maintenance after dieting.

Nearly half of people with obesity who participate in weight loss programmes regain the lost weight within five years. The mechanism driving this weight regain is unknown, but it may be related to cells located in the hypothalamus called AgRP neurons, which have previously been shown to play an important role in regulating hunger. “They are activated when a body is low on fuel, and when they are active, they cause intense hunger,” says Brad Lowell at Beth Israel Deaconess Medical Center in Massachusetts.

Many different brain regions send signals to AgRP neurons through connections known as synapses. These connections can strengthen or weaken, altering the intensity of the signals that travel along them – the stronger the connection, the louder the message.

To see how weight loss affects these synapses, Lowell and his team measured activity in the post-mortem brains of nine mice, five of whom fasted for 16 hours before their brains were examined. The researchers stimulated brain regions known to signal to AgRP neurons using optogenetics, a technique that activates cells using light. In response, mice that fasted had more activity in a part of the hypothalamus called the paraventricular hypothalamic nucleus (PVH) than mice that didn’t fast. This brain region is known to be involved in metabolism and growth.

The researchers silenced these PVH neurons in a separate group of mice that fasted and then tracked how much food the mice ate in 24 hours. On average, the mice ate about 33 per cent less food than mice in a control group, and they regained less weight over the course of seven days. Further experiments revealed that once mice regained the weight they had lost from fasting, the amplified signalling from PVH neurons returned to normal.

Together, these findings suggest that weight regain is driven by a temporary increase in signalling from PVH neurons to AgRP neurons. “Too much hunger is a medical problem and too little hunger is a medical problem,” says Lowell. “If we are going to try to figure out how to address these problems, we need to understand how hunger works.”

These findings are an important step in doing so. Future therapies that dampen the signalling from PVH neurons, for example, could help people maintain weight loss, he says. However, more research is needed to better understand the function of PVH neurons and the consequences of silencing them. “Could you do it without side effects? That we don’t know yet,” says Lowell.

Journal reference: Cell Metabolism DOI: 10.1016/j.cmet.2023.03.002

https://www.newscientist.com/articl...fter-losing-it/
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  #2   ^
Old Sat, Mar-25-23, 05:02
Ms Arielle's Avatar
Ms Arielle Ms Arielle is offline
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Posts: 19,215
 
Plan: atkins, carnivore 2023
Stats: 200/211/163 Female 5'8"
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Progress: -30%
Location: Massachusetts
Default

Wow.

So its likely its not my fault I regain.
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  #3   ^
Old Sat, Mar-25-23, 07:11
Bob-a-rama's Avatar
Bob-a-rama Bob-a-rama is offline
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Plan: Keto (Atkins Induction)
Stats: 235/175/185 Male 5' 11"
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Progress: 120%
Location: Florida
Default

Of course it isn't your faut

Nor mine either

Keto works for me. But it's sometimes very difficult to resist temptation. There are high glycemic foods everywhere, and they taste sooooooo good.

I'm an entertainer, and people who hire us want to feed us. After all, feeding someone is like saying "I love you" and turning it down can hurt their feelings.

So I'll eat what I can, and for what I cannot, I just say, "I'd love to, but -- doctors, orders." They don't have to know the doctor is Dr. Atkins.

The tourist season is almost over, we've been working 6 days per week, and with setting up and tearing down gear, it amounts to 10 hour days. When they northerners go home, there will be less temptation.

Bob
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  #4   ^
Old Sat, Mar-25-23, 16:58
Dodger's Avatar
Dodger Dodger is offline
Posts: 8,764
 
Plan: Paleoish/Keto
Stats: 225/167/175 Male 71.5 inches
BF:18%
Progress: 116%
Location: Longmont, Colorado
Default

Quote:
Nearly half of people with obesity who participate in weight loss programmes regain the lost weight within five years.
One of the reasons for the weight regain is that the weight-loss programs are intended to be short-term and usually calorie restricted. When people get tired of being hungery, they start eating as they did before.
I've been (very) low-carbing for over 20 years and the 55 pounds that I lost years ago have stayed off. If I went back to eating carbs the lost weight would just come back.
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  #5   ^
Old Sat, Mar-25-23, 21:14
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Nancy LC Nancy LC is offline
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Plan: DDF
Stats: 202/185.4/179 Female 67
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Location: San Diego, CA
Default

They did a lot of studies on people that did "The Biggest Loser" and found that they were much hungrier and their metabolisms were far slower than people who had never lost weight or been obese. It was a double-whammy.
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  #6   ^
Old Sun, Mar-26-23, 03:03
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JEY100 JEY100 is offline
Posts: 13,430
 
Plan: P:E/DDF
Stats: 225/150/169 Female 5' 9"
BF:45%/28%/25%
Progress: 134%
Location: NC
Default



If you can’t see yourself doing extended fasting, 20g total carbs, zero carb, carnivore, every day….Forever…Find a healthy, sustainable version of lower carb or any eating pattern that suits you. Many people lose weight and maintain the loss on high carb vegetarian diets, if they commit to doing it forever.

It's not Carbs OR Fats, it is staying away from the hyper palatable Carbs + Fats.
A good explanation by Marty Kendall how to lose weight on any diet and how to keep it off.
https://optimisingnutrition.com/car...-carbs-and-fat/

Last edited by JEY100 : Sun, Mar-26-23 at 03:27.
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  #7   ^
Old Sun, Mar-26-23, 06:47
WereBear's Avatar
WereBear WereBear is online now
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Posts: 14,674
 
Plan: EpiPaleo/Primal/LowOx
Stats: 220/130/150 Female 67
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Progress: 129%
Location: USA
Default

Why is this new? I heard about set points. Decades ago. What it really is, I think, is backsliding into old habits, which gets back the old problems.

That's half of everyone losing weight. But half are keeping it off? Isn't that really good, considering that stat used to be worse?

Of course, we have more unhealthy people now. But it's precisely this kind of "I'll take a pill" thinking that is so difficult to dislodge.
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  #8   ^
Old Sun, Mar-26-23, 10:21
Ms Arielle's Avatar
Ms Arielle Ms Arielle is offline
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Posts: 19,215
 
Plan: atkins, carnivore 2023
Stats: 200/211/163 Female 5'8"
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Progress: -30%
Location: Massachusetts
Default

I ran into a heavy overweight tall man I had not seen for a couple years due to covid restrictions.

I asked how he was, as we both had volunteered at a weeklong bible camp for kids for several years. He had left do to health issues the year before our last year. Our volunteer areas were adjacent.

As we caught up, He endlessly complained about needing knee replacement surgery. I shared that it wasn't without problems, based on FIL. And then shared how eating flour sugar and corn starch on homemade orange chicken had made my body hurt that night. He was very firm that he was not changing his diet. He wanted the foods he loved. And as a diabetic he didnt eat sugar.

I then explained that carbohydrates turned into sugar. He repeated he wanted to eat want he wants. He'd rather be dead. I looked at the loaf of white bread in his cart. Then looked at chicken case and said my good byes. As he limped painfully away.

He is expecting surgery to fix the pain.

I wanted to scream its the diet.

And said good bye in my heart.

Getting the weight off..... and keeping it off is a challenge.

I am grateful to the members of this forum, sharing, teaching, encouraging.

Getting the weigh off is half the battle. Keeping it off is half the battle.
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  #9   ^
Old Mon, Mar-27-23, 05:07
WereBear's Avatar
WereBear WereBear is online now
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Plan: EpiPaleo/Primal/LowOx
Stats: 220/130/150 Female 67
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Progress: 129%
Location: USA
Default

Quote:
Originally Posted by Ms Arielle
He repeated he wanted to eat want he wants. He'd rather be dead.

...

He is expecting surgery to fix the pain.


He's encouraged to think that way. Because doctors have solved a problem for people who have serious joint issues. When the difference between having it and not having it is so big the side effects really don't matter. They are rightly proud. But we have reached diminishing returns when there is a solution. In cases where the process can be interrupted and healed, it is the body crying out for help.

We're back in acute solutions to chronic problems, which has a terrible track record. Type II diabetes: NOW there actually is a choice. Some people take the pills and surgery and that's a complicated mental issue. Others want to solve the actual problem and change the way they eat.

Over the last few years I've dropped my media contact, partly to work on making my own and partly because it was overwhelming But this new low oxalate thing (which seems to be working!) is about six weeks old and established, and my research shifted to a broader range, from Nina Teicholz to people who expose the pyramid schemes behind green smoothies and "fasting lessons."

All to help people pretend to try they are changing the way they eat but it is very difficult. That's why gimmicks like NOOM and "30 pounds in 30 days" keep selling. Because no one can teach you a realization, one has to work at it.

Imagine we knew someone who was always drinking and driving and getting in wrecks and they say they can't change the way they drive. This is how they LIKE to drive and it's how they LIKE to drink and it's someone else's fault their license has been lifted because they should be able to do what they want. And it works that way for food, because it is addictive. It can be explained with addict behaviors.

In my experience with autoimmune, I think doctors don't want to talk about side effects, and so they don't. My independent pharmacist would go over the side effects with a new medication. The corporate bunch I deal with now are not trained to do that. The corporation doesn't police that. So people drift along without adequate prep.

This is "standard of care." I read a memoir where a woman went to a famous multiple sclerosis specialist for "care" and got handed brochures with the instructions to Pick One. (Fortunately for her, it turned out to be a vegan B-12 deficiency.)

And they soothe autoimmune patients with, "it won't kill you. You'll die with it, but it won't be from the disease." No, it will more than likely be some other failing system that the drugs also messed up. OR, in the even worse scenario from my POV, a sudden, raging, infection. But it won't be autoimmune, so relax.

Granted, I think doctors suffer from this system in that they are upset and sorry, on some level, about not being able to do anything. So much that they block out anything else but getting through another sad new session. (I have met so many clinically depressed ex-oncologists, for some reason...)

As a doctor, they have the ability to say, "this is standard of care, and these are the side effects. Here is an alternative you can try, no downside in trying, that works for many people." And some of them are taking it. My doctor loves what I'm doing, and is very supportive.

Now that is what I call a Standard. One might even say, a fair Standard.
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  #10   ^
Old Fri, Mar-31-23, 15:41
Bob-a-rama's Avatar
Bob-a-rama Bob-a-rama is offline
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Posts: 1,961
 
Plan: Keto (Atkins Induction)
Stats: 235/175/185 Male 5' 11"
BF:
Progress: 120%
Location: Florida
Default

Fortunately, I had a doctor (now retired) who suggested diet changes first, medicine next, and anything invasive as a last resort.

I got the Arthritis/Bursitis diet from him back in the early 2000s, it's compatible with keto (I was already on Atkins), and I've been on that diet ever since.

The diet includes no chicken or eggs because of the high A.A. and as much as I love them, I'd rather live pain free with my original hips and hands.
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  #11   ^
Old Tue, Apr-04-23, 07:46
WereBear's Avatar
WereBear WereBear is online now
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Posts: 14,674
 
Plan: EpiPaleo/Primal/LowOx
Stats: 220/130/150 Female 67
BF:
Progress: 129%
Location: USA
Default

Quote:
Originally Posted by Bob-a-rama
... as much as I love them, I'd rather live pain free with my original hips and hands.


I try not to love anything that doesn't "love me back." Likewise, I eat what some people would consider a highly restrictive diet, but it gives me better energy and mobility, not to mention keeping my own autoimmune issues "in remission."

I don't see it that way. I think it's eating certain things which creates the autoimmune. It creates a form of malnutrition, and there are many symptoms.
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  #12   ^
Old Tue, Apr-04-23, 11:00
GRB5111's Avatar
GRB5111 GRB5111 is offline
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Posts: 4,041
 
Plan: Very LC, Higher Protein
Stats: 227/186/185 Male 6' 0"
BF:
Progress: 98%
Location: Herndon, VA
Default

Quote:
Originally Posted by Demi
These findings are an important step in doing so. Future therapies that dampen the signalling from PVH neurons, for example, could help people maintain weight loss, he says. However, more research is needed to better understand the function of PVH neurons and the consequences of silencing them. “Could you do it without side effects? That we don’t know yet,” says Lowell.

This dynamic becomes more fascinating, as we unravel signals that increase hunger and those that signal satiety. I believe many on this forum are able to dampen hunger signals (PVH neuron function) already and are doing it without side effects. I also believe that when one is fat adapted and can readily substitute fat for energy when glycogen stores are low are likely dampening these signals. That's my hypothesis. Anyone who is used to fasting or IF is a good candidate for this, as we don't get hungry when we switch to burning fat. Also, I'd like to see more research related to the ability to readily burn fat and whether the protein leverage hypothesis has any relationship to this dynamic as well. We know that protein helps people become satiated more quickly than the other two macros, so it goes to reason that protein consumption in a fat burner may be the holy grail. However, I can understand where they're going with this, as expensive research funding is only paid back by developing a drug that can dampen PVH neurons. Stay tuned.
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  #13   ^
Old Tue, Apr-04-23, 13:44
Bob-a-rama's Avatar
Bob-a-rama Bob-a-rama is offline
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Posts: 1,961
 
Plan: Keto (Atkins Induction)
Stats: 235/175/185 Male 5' 11"
BF:
Progress: 120%
Location: Florida
Default

Quote:
Originally Posted by WereBear
I try not to love anything that doesn't "love me back." <...snip...>
That's a great way to put it!!!

My taste buds govern what I enjoy eating.

My body governs what is good or detrimental for me to eat.

My brain tells me to eat only things that both taste good and are good, and to avoid the things that don't taste good or are detrimental to me.

I've been low carb since it was called Atkins, and Dr. Bob A. was still alive (70s? 80s?). I'm the only person in my family under 300 pounds. And since I went Atkins/Keto, I have not gained it back.

Of course, I keep tabs on my weight, so if I start drifting back up, I take corrective action.

I happen to like life, I watched my parents die too quickly due to obesity related diseases, and I don't want to check out early. That's my incentive.

Bob
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