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  #1   ^
Old Tue, Aug-17-10, 01:57
Unfinished Unfinished is offline
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Plan: Carnivore
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Default Obesity and diabetes linked by immune cells

Quote:
Media Release 15 August 2010 STRICTLY EMBARGOED TO 10.30AM SUNDAY 15 AUGUST 2010 AEST Obesity and diabetes: immune cells in fat tissue explain the link Inflammation-causing cells in fat tissue may explain the link between obesity and diabetes, a team of Walter and Eliza Hall Institute researchers has shown. The discovery, by Professor Len Harrison and Dr John Wentworth from the institute’s Autoimmunity and Transplantation division, opens the way for new anti-inflammatory treatments that prevent insulin resistance (where the body is unable to respond to and use the insulin it produces) and other complications associated with obesity. “We have shown that insulin resistance in human obesity is closely related to the presence of inflammatory cells in fat tissue, in particular a population of macrophage cells,” Professor Harrison said. Macrophages, white blood cells derived from the bone marrow, are immune cells that normally respond to infections. In obese people, macrophages move into the fat tissue where they cause inflammation and release cytokines, which are chemical messenger molecules used by immune cells to communicate. Certain cytokines cause cells to become resistant to the effects of the hormone insulin, leading to diabetes and heart disease. Professor Harrison and Dr Wentworth worked with Mr Gaetano Naselli, Ms Belinda Phipson and Dr Gordon Smyth at the institute as well as Professor Paul O’Brien at Monash University’s Centre for Obesity Research and Education to analyse the fat tissue of more than 100 Victorians who had undergone lapband surgery. Their findings, published in the journal Diabetes, provide the first evidence in humans that macrophages in the fat tissue are producing cytokines that prevent cells from appropriately responding to the presence of insulin. “The complications of obesity such as insulin resistance and diabetes, cardiovascular disease associated with hardening of the arteries, and liver problems are the result of inflammation that occurs in the fat tissue,” Professor Harrison said. “These complications could be prevented by developing drugs that target certain cytokines released by the macrophages. “Encouragingly, our study also showed that when obese people lost weight the macrophages in the fat tissue disappeared, as did the risk of developing insulin resistance and diabetes.” Diabetes affects more than a million Australians and is a disease in which the body does not produce or properly use insulin, a hormone necessary to convert sugar, starches and other food into the energy needed for daily life. The research was supported by the Australian National Health and Medical Research Council, the Victorian Government, Diabetes Australia Research Trust and the Royal Australian College of Physicians Research Foundation. For more information contact Penny Fannin, Strategic Communications Manager on +61 3 9345 2345 begin_of_the_skype_highlighting~~~~~~~~~~~~~~+61 3 9345 2345~~~~~~end_of_the_skype_highlighting begin_of_the_skype_highlighting~~~~~~~~~~~~~~+61 3 9345 2345~~~~~~end_of_the_skype_highlighting, 0417 125 700 or fannin~wehi.edu.au.


This sounds promising.

Cheryl
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  #2   ^
Old Tue, Aug-17-10, 09:14
Hutchinson's Avatar
Hutchinson Hutchinson is offline
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Plan: Dr Dahlqvist's
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opens the way for new anti-inflammatory treatments


But in a world where most people are deficiency in Vitamin D3 a NATURAL ANTI INFLAMMATORY AGENT wouldn't correcting vitamin D deficiency first be a sensible idea. 5000iu/daily D3 is cheap enough and less than half the amount full body midday non burning sun exposure would produce. Keeping levels above 50ng/ml means you always have a stored reserve of vitamin D3 as we only begin to store D3 above 40ng/ml.

Only 10% of US adults actually consume the daily RDA for magnesium and because higher omega 6 levels leads to increased excretion of magnesium the current RDA is probably insufficient now anyway. Albion Magnesium chelates are not that expensive however one of the best absorbed forms is magnesium bicarbonate water and that is even cheaper to make.

Magnesium, inflammation, and obesity in chronic disease.

We should also recognise that most USA adults are suffering high levels of inflammation from the amount of omega 6 oils in their systemsand that it is this that is the primary source of the excess inflammation.
http://images.quickblogcast.com/8/9...6chart.png?a=17 Oils in the US Food Supply in the 20th Century
Much as I would like everyone to consume more Concentrated omega 3 fish oil we have to recognise that above a ratio of 5<> 1 the omega 6 displaces omega 3 so we won't see the amount of improvement we would like until the ratio of omega 6 is lowered and that means eliminating ndustrial seed oils such as corn, soybean, safflower, sunflower and cottonseed oil and all the commercially made foods that contain them and by extension the intensively reared meat that has been fattened using high omega 6 containing foods, primarily poultry.
Although increasing omega 3 intake is fairly instant in raising plasma omega 3 levels the half life of omega 6 is 2 yrs so even if you stopped consuming all high omega 6 sources today it will be more than a couple of years before your ratio of omega 6 is approaching the level your DNA evolved to work best with. but obviously the sooner you start the better.

My main point is that we do not really require NEW anti inflammatory treatments we simply need to reinstate the natural anti inflammatory status our bodies would naturally achieve eating pasture raised meats and traditional oils and fats.

If anyone wants to follow may suggestions above for sources of anti inflammatory supplements introductory code ~~~~~~ saves $5.

Don't know why the image didn't appear. It comes from This new posting from Evelyn Tribole

Last edited by Hutchinson : Tue, Aug-17-10 at 09:56.
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  #3   ^
Old Fri, Aug-20-10, 18:45
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NewRuth NewRuth is offline
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Plan: LC gut healing
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Quote:
Originally Posted by Hutchinson
My main point is that we do not really require NEW anti inflammatory treatments we simply need to reinstate the natural anti inflammatory status our bodies would naturally achieve eating pasture raised meats and traditional oils and fats.

But, that's not patentable, so there's no $$$ in it.

I've been working to eliminate omega 6's from my diet. They seem to hide everywhere!
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  #4   ^
Old Mon, Aug-23-10, 06:58
renegadiab renegadiab is offline
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Posts: 475
 
Plan: Schwarzbein/Bernstein
Stats: 355/240/200 Male 69 inches
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Quote:
Originally Posted by Hutchinson
But in a world where most people are deficiency in Vitamin D3 a NATURAL ANTI INFLAMMATORY AGENT wouldn't correcting vitamin D deficiency first be a sensible idea. 5000iu/daily D3 is cheap enough and less than half the amount full body midday non burning sun exposure would produce. Keeping levels above 50ng/ml means you always have a stored reserve of vitamin D3 as we only begin to store D3 above 40ng/ml.

Only 10% of US adults actually consume the daily RDA for magnesium and because higher omega 6 levels leads to increased excretion of magnesium the current RDA is probably insufficient now anyway. Albion Magnesium chelates are not that expensive however one of the best absorbed forms is magnesium bicarbonate water and that is even cheaper to make.

Magnesium, inflammation, and obesity in chronic disease.

We should also recognise that most USA adults are suffering high levels of inflammation from the amount of omega 6 oils in their systemsand that it is this that is the primary source of the excess inflammation.
http://images.quickblogcast.com/8/9...6chart.png?a=17 Oils in the US Food Supply in the 20th Century
Much as I would like everyone to consume more Concentrated omega 3 fish oil we have to recognise that above a ratio of 5<> 1 the omega 6 displaces omega 3 so we won't see the amount of improvement we would like until the ratio of omega 6 is lowered and that means eliminating ndustrial seed oils such as corn, soybean, safflower, sunflower and cottonseed oil and all the commercially made foods that contain them and by extension the intensively reared meat that has been fattened using high omega 6 containing foods, primarily poultry.
Although increasing omega 3 intake is fairly instant in raising plasma omega 3 levels the half life of omega 6 is 2 yrs so even if you stopped consuming all high omega 6 sources today it will be more than a couple of years before your ratio of omega 6 is approaching the level your DNA evolved to work best with. but obviously the sooner you start the better.

My main point is that we do not really require NEW anti inflammatory treatments we simply need to reinstate the natural anti inflammatory status our bodies would naturally achieve eating pasture raised meats and traditional oils and fats.

If anyone wants to follow may suggestions above for sources of anti inflammatory supplements introductory code ~~~~~~ saves $5.

Don't know why the image didn't appear. It comes from This new posting from Evelyn Tribole


That would be the best solution, but diet and cheap supplements don't make $$$$ for the medical establishment. Anyt time they find something that could be helped with simple lifestyle changes, they have to look for a drug or medical procedure instead. It wouldn't surprise me if they start pushing statins to control diabetes because of the inflammation factor. Never mind that diabetes increased in the treatment group of the JUPITER study.....
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  #5   ^
Old Mon, Aug-23-10, 07:30
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WereBear WereBear is offline
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Plan: EpiPaleo/Primal/LowOx
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Quote:
Originally Posted by renegadiab
It wouldn't surprise me if they start pushing statins to control diabetes because of the inflammation factor. Never mind that diabetes increased in the treatment group of the JUPITER study.....


They already ARE pushing statins for Alzheimer's, diabetes, and Parkinson's; despite some evidence that statins can cause such.

Then again, I've had people flat out tell me; "I don't want to change my lifestyle, I just want to take a pill." There's yer market.
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