Active Low-Carber Forums
Atkins diet and low carb discussion provided free for information only, not as medical advice.
Home Plans Tips Recipes Tools Stories Studies Products
Active Low-Carber Forums
A sugar-free zone


Welcome to the Active Low-Carber Forums.
Support for Atkins diet, Protein Power, Neanderthin (Paleo Diet), CAD/CALP, Dr. Bernstein Diabetes Solution and any other healthy low-carb diet or plan, all are welcome in our lowcarb community. Forget starvation and fad diets -- join the healthy eating crowd! You may register by clicking here, it's free!

Go Back   Active Low-Carber Forums > Main Low-Carb Diets Forums & Support > Low-Carb Studies & Research / Media Watch > LC Research/Media
User Name
Password
FAQ Members Calendar Mark Forums Read Search Gallery My P.L.A.N. Survey


Reply
 
Thread Tools Display Modes
  #1   ^
Old Sun, May-01-22, 03:40
Demi's Avatar
Demi Demi is offline
Posts: 24,384
 
Plan: HP/LC/IF
Stats: 238/180/160 Female 5'10"
BF:
Progress: 74%
Location: UK
Default 'Keto' molecule may be useful in preventing and treating colorectal cancer

Quote:
'Keto' molecule may be useful in preventing and treating colorectal cancer, study suggests

A molecule produced in the liver in response to low-carb "ketogenic" diets has a powerful effect in suppressing colorectal tumor growth and may be useful as a preventive and treatment of such cancers, according to a new study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

In the study, published in Nature, researchers initially found that mice on low-carb, high-fat ketogenic diets have a striking resistance to colorectal tumor development and growth. The scientists then traced this effect to beta-hydroxybutyrate (BHB), a small organic molecule produced in the liver in response to keto diets or starvation.

"Our findings suggest that this natural molecule, BHB, could someday become a standard part of colorectal cancer care and prevention," said study co-senior author Maayan Levy, PhD, an assistant professor of Microbiology at Penn Medicine, whose laboratory collaborated with the lab of Christoph Thaiss, PhD, also an assistant professor of Microbiology. The study's first author was Oxana Dmitrieva-Posocco, PhD, a postdoctoral researcher in Levy's lab.

Colorectal cancer is one of the most common cancer types and kills more than 50,000 Americans annually, making it the country's third leading cause of cancer mortality. Alcohol use, obesity, red meat, and low-fiber and high-sugar diets have all been linked to greater colorectal cancer risk.

In the study, Levy, Thaiss and their teams set out to determine, with experiments in mice, whether different types of diet could inhibit colorectal cancer development and growth. They put six groups of mice on diets that had varying fat-to-carb ratios, and then used a standard chemical technique that normally induces colorectal tumors.

They found that the two most ketogenic diets, with 90 percent fat-to-carb ratios -- one used lard (pig fat), the other Crisco (mostly soybean oil) -- prevented colorectal tumor development in most of the animals on those diets. By contrast, all the animals on the other diets, including low-fat, high-carb diets, developed tumors. Even when the researchers started the mice on these diets after colorectal tumors had started growing, the diets showed a "treatment effect" by markedly slowing further tumor growth and proliferation.

In subsequent experiments, the scientists determined that this tumor suppression is associated with a slower production, by stem cells, of new epithelial cells lining the colon. Ultimately, they traced this gut-cell growth slowdown to BHB -- normally produced by the liver as part of a "starvation response," and triggered in this case by the low-carb keto diets.

BHB is known to work as an alternative fuel source for key organs in low-carb conditions. However, the researchers showed that it is not only a fuel source but also a potent growth-slowing signal, at least for gut-lining cells. They were able to reproduce the tumor-suppressing effects of the keto diets simply by giving the mice BHB, either in their water or via an infusion mimicking the liver's natural secretion of the molecule.

The team showed that BHB exerts its gut-cell growth-slowing effect by activating a surface receptor called Hcar2. This in turn stimulates the expression of a growth-slowing gene, Hopx.

Experiments with gut-lining cells from humans provided evidence that BHB has the same growth-slowing effect on these cells, via the human versions of Hcar2 and Hopx. Colorectal tumor cells that don't express these two genes were not responsive to BHB treatment, suggesting their utility as possible predictors of treatment efficiency.

"Clinical trials of BHB supplementation are needed before any recommendation can be made about its use in prevention or treatment," Thaiss said.

The researchers are now setting up just such a clinical trial of BHB -- which is widely available as a dieting supplement -- in colorectal cancer patients. They are also continuing to study BHB's potential anticancer effects in other parts of the body, and are investigating the effects of other molecules produced under ketogenic conditions.

The study was funded by the National Institutes of Health (R01 CA218133, R01 CA227629, P30 CA-006927, DP2AG067511, P30 ES013508, DP2AG067492, P30-DK-050306, P30-AR-069589, P30-DK-019525), the BSF US-Israel Foundation, the Searle Scholar program, the Pew Charitable Trust, the Edward Mallinckrodt, Jr. Foundation, the Abramson Cancer Center, the Borrelli Family, the Global Probiotics Council, the National Mouse Metabolic Phenotyping Centers, the IDSA Foundation, and the Thyssen Foundation.


Journal Reference:

Oxana Dmitrieva-Posocco, Andrea C. Wong, Patrick Lundgren, Aleksandra M. Golos, Hélène C. Descamps, Lenka Dohnalová, Zvi Cramer, Yuhua Tian, Brian Yueh, Onur Eskiocak, Gabor Egervari, Yemin Lan, Jinping Liu, Jiaxin Fan, Jihee Kim, Bhoomi Madhu, Kai Markus Schneider, Svetlana Khoziainova, Natalia Andreeva, Qiaohong Wang, Ning Li, Emma E. Furth, Will Bailis, Judith R. Kelsen, Kathryn E. Hamilton, Klaus H. Kaestner, Shelley L. Berger, Jonathan A. Epstein, Rajan Jain, Mingyao Li, Semir Beyaz, Christopher J. Lengner, Bryson W. Katona, Sergei I. Grivennikov, Christoph A. Thaiss, Maayan Levy. β-Hydroxybutyrate suppresses colorectal cancer. Nature, 2022; DOI: 10.1038/s41586-022-04649-6

https://www.sciencedaily.com/releas...20427115716.htm
Reply With Quote
Sponsored Links
  #2   ^
Old Sun, May-01-22, 06:39
GRB5111's Avatar
GRB5111 GRB5111 is offline
Posts: 3,839
 
Plan: Very LC, Higher Protein
Stats: 227/186/185 Male 6' 0"
BF:
Progress: 98%
Location: Herndon, VA
Default

Very exciting research in this area. Thanks, Demi.
Reply With Quote
  #3   ^
Old Sun, May-01-22, 07:07
WereBear's Avatar
WereBear WereBear is offline
Senior Member
Posts: 13,686
 
Plan: Epi-Paleo/IF
Stats: 220/125/150 Female 67
BF:
Progress: 136%
Location: USA
Default

It's almost like it's a metabolic origin for many cancers!
Reply With Quote
  #4   ^
Old Sun, May-01-22, 16:41
Dodger's Avatar
Dodger Dodger is offline
Posts: 8,625
 
Plan: Paleoish/Keto
Stats: 225/165/175 Male 71.5 inches
BF:18%
Progress: 120%
Location: Longmont, Colorado
Default

So, not eating carbs prevents colorectal cancer. I wonder how the high-carb advocates will spin the data.
Reply With Quote
  #5   ^
Old Mon, May-02-22, 06:10
WereBear's Avatar
WereBear WereBear is offline
Senior Member
Posts: 13,686
 
Plan: Epi-Paleo/IF
Stats: 220/125/150 Female 67
BF:
Progress: 136%
Location: USA
Default

Quote:
Originally Posted by Dodger
So, not eating carbs prevents colorectal cancer. I wonder how the high-carb advocates will spin the data.


My guess is people should eat more fiber.
Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off



All times are GMT -6. The time now is 23:03.


Copyright © 2000-2022 Active Low-Carber Forums @ forum.lowcarber.org
Powered by: vBulletin, Copyright ©2000 - 2022, Jelsoft Enterprises Ltd.