We might be adapted to eat cooked food--but, are we adapted to eat cooked food in our modern environment, cooked food when we're carbohydrate intolerant, fat intolerant, have leaky guts, etc.?
I was looking at this last night, an argument for how low fat addresses insulin resistance. Of course it has to throw low carbohydrate under the bus while it's at it.
http://www.forksoverknives.com/fat-...ce-blood-sugar/
file:///C:/Users/donald/Downloads/archinte_40_6_005.pdf
It links some classic studies. In this one, normal subjects were fed diets of almost pure protein, carbohydrate, or fat for two days, or fasted.
Glucose tolerance on the third day was best in the group that ate high carb, then high protein, the starvation and fat-fed groups were identical.
Jeff Volek has shown a similar thing with fat tolerance, by the way, put people on very high-fat diets, and the postprandial rise in triglycerides after a fat load decreases quite a bit, with a lower peak and a quicker return to basal.
In the case of the protein--what are the odds that people, especially people new to a high-protein diet, will undereat? Pretty high. Same with the pure-fat diet. This is physiological glucose intolerance, perhaps from an elevation in free fatty acids, but it didn't matter to these non-diabetic subjects until they actually ate some glucose.
http://www.ncbi.nlm.nih.gov/pmc/art...l01610-0047.pdf
Another classic study by another author. It's feeding bunnies a high fat diet (at least for bunnies) so I wouldn't take it too seriously, but it's still a fun read.
http://www.ncbi.nlm.nih.gov/pubmed/0010480616
And something more recent...
Quote:
Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.
Santomauro AT1, Boden G, Silva ME, Rocha DM, Santos RF, Ursich MJ, Strassmann PG, Wajchenberg BL.
Author information
Abstract
Obesity is commonly associated with elevated plasma free fatty acid (FFA) levels, as well as with insulin resistance and hyperinsulinemia, two important cardiovascular risk factors. What causes insulin resistance and hyperinsulinemia in obesity remains uncertain. Here, we have tested the hypothesis that FFAs are the link between obesity and insulin resistance/hyperinsulinemia and that, therefore, lowering of chronically elevated plasma FFA levels would improve insulin resistance/hyperinsulinemia and glucose tolerance in obese nondiabetic and diabetic subjects. Acipimox (250 mg), a long-acting antilipolytic drug, or placebo was given overnight (at 7:00 P.M., 1:00 A.M., 7:00 A.M.) to 9 lean control subjects, 13 obese nondiabetic subjects, 10 obese subjects with impaired glucose tolerance, and 11 patients with type 2 diabetes. Euglycemic-hyperinsulinemic clamps and oral glucose tolerance tests (75 g) were performed on separate mornings after overnight Acipimox or placebo treatment. In the three obese study groups, Acipimox lowered fasting levels of plasma FFAs (by 60-70%) and plasma insulin (by approximately 50%). Insulin-stimulated glucose uptake during euglycemic-hyperinsulinemic clamping was more than twofold higher after Acipimox than after placebo. Areas under the glucose and insulin curves during oral glucose tolerance testing were both approximately 30% lower after Acipimox administration than after placebo. We conclude that lowering of elevated plasma FFA levels can reduce insulin resistance/hyperinsulinemia and improve oral glucose tolerance in lean and obese nondiabetic subjects and in obese patients with type 2 diabetes.
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http://www.ncbi.nlm.nih.gov/pubmed/0010480616
There really doesn't seem to be much doubt that elevated free fatty acids plus a glucose load makes for higher insulin requirement, lower glucose tolerance. In GCBC, Gary Taubes suggested that increased insulin sensitivity in the fat tissue specifically might be the major contributor to whole-body insulin sensitivity. Well, maybe. Sounds good when I have my carbohydrate hypothesis hat on--but when I have my insulin hypothesis hat on, that cutting plasma insulin by 50 percent sounds sort of anti-obesogenic.