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  #1   ^
Old Wed, Jul-24-19, 03:16
s93uv3h s93uv3h is offline
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Plan: Atkins & IF / TRE
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Default Diabetes & Metabolic Syndrome: Clinical Research & Reviews - March April 2019

Diabetes & Metabolic Syndrome: Clinical Research & Reviews - March April 2019

Abstract

It has been established that there is a correlation between Alzheimer's disease and apolipoprotein E, specifically the ApoE4 genetic variant. However, the correlation between Apoe4, insulin resistance and metabolic syndrome (MetS) pathologies still remains elusive. As apolipoprotein E has many important physiological functions, individuals with the ApoE4 allele variant, also known as the Alzheimer's disease gene, are primarily at a greater risk for physiological consequences, specifically cognitive impairment (Chan et al., 2016). In this case study, a 71-year old female, heterozygous for ApoE4 with a family history of Alzheimer's Disease (AD) and the dual diagnosis of mild AD/metabolic syndrome (MetS) was placed on a 10-week nutrition protocol purposed at raising plasma ketones through carbohyrdrate restricted, high fat ketogenic diet (KD), time- restricted eating and physical/cognitive exercise. Primary biomarkers for MetS were measured pre/mid-/post intervention. The MoCA (Montreal Cognitive Assessment) was administered pre/post intervention by a licensed clinical therapist. The results were statistically significant. The HOMA-IR decreased by 75% from 13.9 to 3.48. Triglycerides decreased by 50% from 170mg/dL to 85mg/dL. VLDL dropped by 50% from 34mg/dL to 17mg/dL, and HgA1c decreased from 5.7% to 4.9%. The baseline MoCA score was 21/30; post treatment score was 28/30. The significant results in both MetS biomarkers and the MoCA score suggest that a ketogenic diet may serve to rescue cognition in patients with mild AD. The results of this case study are particularly compelling for ApoE4 positive (ApoE4+) subjects as ketogenic protocols extend hope and promise for AD prevention.
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  #2   ^
Old Wed, Jul-24-19, 05:37
Dodger's Avatar
Dodger Dodger is offline
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Plan: Paleoish
Stats: 225/170/175 Male 71.5 inches
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Location: Longmont, Colorado
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That's a very interesting N=1 study. If an Alzheimer drug had that result, it would be called a miracle cure.
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  #3   ^
Old Wed, Jul-24-19, 07:18
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GRB5111 GRB5111 is offline
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Plan: Ketogenic (LCHFKD)
Stats: 227/186/185 Male 6' 0"
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Location: Herndon, VA
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While this is an N=1, I wonder what a preventive keto protocol would do for those who have been confirmed with the ApoE4 allele variant? Could it serve to delay or reduce Alzheimer's symptoms?
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