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  #1   ^
Old Tue, May-03-22, 08:52
Nancy LC's Avatar
Nancy LC Nancy LC is offline
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Default The Role of the Agouti-Related Protein in Energy Balance Regulation

Discovery of key regulator of body weight could lead to new treatments for metabolic disorders

Quote:
Yale scientists uncover key regulator of body weight.

Yale scientists have discovered that a protein known as augmentor-alpha regulates body weight in mice, an insight that could lead to new treatments for metabolic disorders.

The findings were published April 11 in the Proceedings of the National Academy of Sciences.

The research team decided to take a closer look at augmentor-alpha because of its connection to cancer. The protein is known to bind to and activate the anaplastic lymphoma kinase receptor (ALK), a molecule that, when mutated, drives a variety of human cancers, including pediatric neuroblastoma, B-cell lymphomas, and certain lung cancers.

To better understand this protein and the role it plays in the body, Yale researchers first wanted to pinpoint where it is commonly located. Looking in mice, they found that augmentor-alpha was most strongly expressed in the hypothalamus region of the brain.

In particular, they found it was expressed within cells called agouti-related peptide (AgRP) neurons, which are known to promote hunger.

... More at link


The Role of the Agouti-Related Protein in Energy Balance Regulation The official paper.
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  #2   ^
Old Wed, May-04-22, 10:43
WereBear's Avatar
WereBear WereBear is offline
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Default

Oh, for heaven's sake. They just don't have a good track record when it comes to manipulating these aspects of body chemistry.

Nothing can offset a bad diet.
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  #3   ^
Old Thu, May-05-22, 05:29
WereBear's Avatar
WereBear WereBear is offline
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Default

Also, I keep laughing about it when I see it because "agouti" is what causes the stripes on tabby cats.
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  #4   ^
Old Thu, May-05-22, 07:58
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Ms Arielle Ms Arielle is offline
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Plan: atkins
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Lol, it's a basic coat color in many animals, lol. A wild type.

Looks like a very long connection , thru millions of years.
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  #5   ^
Old Thu, May-05-22, 08:14
Nancy LC's Avatar
Nancy LC Nancy LC is offline
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Well, people like me who have a very "good" diet and can't lose weight would welcome some sort of help. The more we know.
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  #6   ^
Old Thu, May-05-22, 10:59
WereBear's Avatar
WereBear WereBear is offline
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Plan: Epi-Paleo/IF
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Quote:
Originally Posted by Nancy LC
Well, people like me who have a very "good" diet and can't lose weight would welcome some sort of help. The more we know.


Oh, definitely. I got DH and myself 23andMe for last holiday season, and I'm getting back things that haven't been a deal changer yet, but might yet be. And I haven't even got hard core and run them through those other analyzers yet.

We shouldn't stop investigating and think we know it all. I once thought I had it all figured out
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  #7   ^
Old Thu, May-05-22, 11:11
Nancy LC's Avatar
Nancy LC Nancy LC is offline
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Plan: DDF
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We have no idea what things are messing with us in our environment. It's time to stop blaming fat people for being fat and maybe take a little harder look at what the underlying cause is, other than crappy diets.
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  #8   ^
Old Thu, May-05-22, 13:27
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deirdra deirdra is offline
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Quote:
Originally Posted by Ms Arielle
Lol, it's a basic coat color in many animals, lol. A wild type.
Yes, I thought of my cats as soon as I saw it. Eating real, unprocessed food like a wild cat works best for me and restored my natural appetite, so I don't need to read the mouse article!

Last edited by deirdra : Thu, May-05-22 at 13:39.
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  #9   ^
Old Thu, May-26-22, 09:11
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teaser teaser is offline
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Default

Might be something interesting to learn about anorexia here as well.

I always find blaming popular culture, everybody wants to look like Barbie, or Ziggy, or whatever's currently hip, a bit much. Even when somebody wants to starve themselves to be thin, most people will fail in the long term, many of us even in the short term. Something has to be different in people who actually become anorexic. I tend to think physiology generally wins out, and our cognitive selves run along behind, fabricating explanations.
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  #10   ^
Old Thu, May-26-22, 16:06
Dodger's Avatar
Dodger Dodger is offline
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Plan: Paleoish/Keto
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Quote:
Originally Posted by teaser
I always find blaming popular culture, everybody wants to look like Barbie, or Ziggy, or whatever's currently hip, a bit much.

Ziggy or Twiggy?
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  #11   ^
Old Fri, May-27-22, 06:45
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WereBear WereBear is offline
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Plan: Epi-Paleo/IF
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Default

Quote:
Originally Posted by teaser
I tend to think physiology generally wins out, and our cognitive selves run along behind, fabricating explanations.


As the saying goes, we're not rational beings. We just think we are, because we are rationalization beings.
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