Fri, Aug-10-18, 06:22
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Senior Member
Posts: 15,075
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Plan: mostly milkfat
Stats: 190/152.4/154
BF:
Progress: 104%
Location: Ontario
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Dietary carbohydrates could lead to osteoarthritis, new study finds
https://www.sciencedaily.com/releas...80809112417.htm
The carbs being accused here are sugar and insoluble fiber (cellulose).
Quote:
Do your knees ache? According to new findings from the Oklahoma Medical Research Foundation, your diet could be a culprit.
In a study led by OMRF scientist Tim Griffin, Ph.D., researchers found that the carbohydrate composition of diets increased the risk of osteoarthritis in laboratory mice -- even when the animals didn't differ in weight.
"We know increased body fat elevates risk, but we haven't appreciated as much how diet itself affects the disease risk," said Griffin. "These findings give us new clues that there can be significant dietary effects linked to increased OA risk even in the absence of obesity."
Osteoarthritis, or OA, is the most common form of arthritis and the most widespread form of disability in the country, affecting nearly 27 million people in the U.S. It occurs when the cartilage that cushions bones in the joints breaks down and wears away, causing the bones to rub against one another.
Several factors can increase risk, including high-impact physical jobs, previous joint injuries, age and genetics, but carrying extra body weight is among the most proven contributors.
"Obesity is the one of the most significant factors for developing disease in the knee joint," said Griffin. "However, therapeutic strategies to prevent or treat obesity-associated OA are limited because of the uncertainly about the root cause of the disease."
To study how, exactly, obesity contributes to osteoarthritis, Griffin and his lab placed groups of mice on different high-fat diets. However, over time, they observed that the carbohydrate makeup of the rodents' low-fat control diet was alone sufficient to alter their chances of developing OA.
The primary culprits: fiber and sugar.
In particular, Griffin's team found that changing the amount of sucrose -- table sugar -- and fiber in the diet altered OA pathology in the rodents. The high-sucrose diet increased signs of joint inflammation, while the high-fiber diet caused changes in cartilage genes and cellular stress-response pathways.
While the study involved mice, Griffin said the findings could ultimately have human implications.
"It's important to understand how our diet affects the health of our joints," he said. "We were surprised to see so many OA-related differences between the two high-carb diets even though body weight and body fat were the same."
Griffin next plans to investigate how different types of dietary fiber and other components of our diets can contribute to OA, and also look at the role the body's microbiome and gut bacteria play in the disease.
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Fiber?
Quote:
However, the use of cellulose as an insoluble
fiber supplement in many purified defined diets, such as those used in the current study, causes
substantial changes in gut morphology and microbiota content compared to chow-fed mice
(Chassaing et al., 2015; Dalby et al., 2017). These changes may underlie our findings indicating
Disease Models & Mechanisms • DMM • Accepted manuscript
that the LFLS diet was moderately stressful to the mice. Numerous serum metabolic biomarkers
were elevated in the LFLS diet group, including serum albumin, bilirubin, gammaglutamyltransferase,
globulins, protein, and urea nitrogen.
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http://dmm.biologists.org/content/d...034827.full.pdf
Okay, cellulose. There's a study called "A ketogenic diet results in a unique metabolic state in mice" or some such that had to be restarted six months in when the mice on the ketogenic diet were dying too early--switching from cellulose to wheat middlings allowed the animals to live long enough for the purposes of the study. Another study looked at 25 different diets, of varying macronutrient ratios and calorie density. Calorie density was controlled by varying amounts of cellulose. Regardless of macro ratio, the low density, high cellulose mice all died early, the most obviously interesting finding. So the headline was based on a mild effect of varying carb/protein content. 
Celery isn't in my diet right now, but for the record, I'm not that paranoid about eating it or not eating it.
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