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  #1   ^
Old Tue, Jan-15-19, 16:17
s93uv3h s93uv3h is online now
 
Plan: Atkins & IF / TRE
Stats: 000/014.5/015 Male 5' 10"
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Default Consumption of a dark roast coffee blend reduces DNA damage in humans

referenced in Dr. Rhonda Patrick's latest instagram post:

Consumption of a dark roast coffee blend reduces DNA damage in humans: results from a 4-week randomised controlled study 11-2018

Abstract
Purpose
To determine the DNA protective effects of a standard coffee beverage in comparison to water consumption.

Methods
The single-blind, randomised controlled study with parallel design included healthy women (n = 50) and men (n = 50) recruited from the general Central European population. The subjects were randomised in a coffee and a control group, with stratification for sex and body mass index. The study comprised two periods of 4 weeks: a preconditioning period, with daily consumption of at least 500 ml water but no coffee, nor tea, nor any other caffeine-containing product. During the subsequent intervention period the coffee group consumed 500 ml of freshly brewed dark roast coffee blend per day, the control group consumed water instead. On the last day of each period, blood was drawn and analysed by comet assay (single-cell gel electrophoresis) to assess the level of DNA damage (strand breakage).

Results
At the end of the intervention period the mean level of DNA strand breaks in the coffee group has decreased in comparison to the control group [difference in means 0.23% TI (tail intensity), p = 0.028]. The mean change from baseline (delta value) was − 23% in the coffee group (p = 0.0012). Effects of coffee intake were similar for men and women. During intervention, neither group showed any significant change in body weight or calorie intake.

Conclusions
Our results indicate that regular consumption of a dark roast coffee blend has a beneficial protective effect on human DNA integrity in both, men and women.
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  #2   ^
Old Tue, Jan-15-19, 16:45
WereBear's Avatar
WereBear WereBear is offline
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Looks like I picked the wrong week to give up coffee.
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  #3   ^
Old Tue, Jan-15-19, 21:31
Verbena Verbena is offline
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And what about tea? (My personal choice; strong, black, sugarless, probably too long brewed, and many cups throughout the day. My main form of hydration)
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  #4   ^
Old Wed, Jan-16-19, 05:12
s93uv3h s93uv3h is online now
 
Plan: Atkins & IF / TRE
Stats: 000/014.5/015 Male 5' 10"
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Progress: 97%
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Quote:
Originally Posted by Verbena
And what about tea? (My personal choice; strong, black, sugarless, probably too long brewed, and many cups throughout the day. My main form of hydration)
hitting the link below automatically downloads the pdf file:

The effects of green tea on weight loss and weightmaintenance: a meta-analysis.

Introduction. Different outcomes of the effect of green tea on weight loss (WL) and weight maintenance (WM) have been reported in studies with subjects differing in ethnicity and habitual caffeine intake.

Purpose. To elucidate by meta-analysis whether green tea indeed has a function in body weight regulation.

Methods. English-language studies about WL and WM after green tea supplementation were identified through PubMed and based on the references from retrieved articles. Out of the 49 studies initially identified, a total of 11 articles fitted the inclusion criteria and provided useful information for the meta-analysis. Effect sizes (mean weight change in treatment versus control group) were computed and aggregated based on a random-effects model. The influence of several moderators on the effect sizes was examined.
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  #5   ^
Old Wed, Jan-16-19, 08:40
WereBear's Avatar
WereBear WereBear is offline
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Plan: Epi-Paleo/IF
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Quote:
Originally Posted by s93uv3h
hitting the link below automatically downloads the pdf file:

The effects of green tea on weight loss and weightmaintenance: a meta-analysis.


Thanks, interesting reading!

I broke down: after a few weeks without, I had a cup of coffee this morning. Enjoyed it, and didn't make my symptoms worse.

On the other hand, I know I can use this power for evil: I can use coffee to prop up a system dysfunction, when I need to realize that something is out of whack and fix it, instead.
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  #6   ^
Old Wed, Jan-16-19, 12:06
Verbena Verbena is offline
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Thanks s93uv3h - I guess I should work harder at trying to like green tea
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  #7   ^
Old Wed, Jan-16-19, 12:10
Meme#1's Avatar
Meme#1 Meme#1 is offline
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I have part of an article way back in my first J that said green tea raised histamine levels.
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  #8   ^
Old Wed, Jan-16-19, 12:32
WereBear's Avatar
WereBear WereBear is offline
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Quote:
Originally Posted by Meme#1
I have part of an article way back in my first J that said green tea raised histamine levels.


It does. Which is why, if you have histamine intolerance, that's a bad thing.
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  #9   ^
Old Wed, Jan-16-19, 15:27
Nancy LC's Avatar
Nancy LC Nancy LC is offline
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Plan: Paleo 99.5%
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Good, in that case I'll never get cancer. I drink so much coffee... LOL! Although I think I've got a skin cancer spot on my arm.
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  #10   ^
Old Wed, Jan-16-19, 15:33
WereBear's Avatar
WereBear WereBear is offline
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Plan: Epi-Paleo/IF
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Quote:
Originally Posted by Nancy LC
Good, in that case I'll never get cancer. I drink so much coffee... LOL! Although I think I've got a skin cancer spot on my arm.


If you stacked up all the pro-coffee and anti-coffee studies, they would be about the same size.

Hope you are getting that arm thing taken care of
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  #11   ^
Old Wed, Jan-16-19, 15:44
CityGirl8 CityGirl8 is offline
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Quote:
Originally Posted by WereBear
If you stacked up all the pro-coffee and anti-coffee studies, they would be about the same size.

Out of curiosity--what are the anti-coffee studies? Mostly I think I've heard of pro-coffee and some anti-excessive caffeine consumption studies. Of course that could my selective memory at work.
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  #12   ^
Old Wed, Jan-16-19, 17:31
WereBear's Avatar
WereBear WereBear is offline
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Plan: Epi-Paleo/IF
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Quote:
Originally Posted by CityGirl8
Out of curiosity--what are the anti-coffee studies? Mostly I think I've heard of pro-coffee and some anti-excessive caffeine consumption studies. Of course that could my selective memory at work.


Nice little roundup here from a pioneering functional medicine doctor:

Ten Reasons to Quit Your Coffee!

Coffee is a psychoactive drug. How it works for an individual varies widely by their genes, their health situation, what kind they drink, and how much & often.

Iíve just come off almost a month without, and wanted to see if it had any immediate ill effects. It doesnít seem to. Still, I plan to keep it to two cups, 2-3 times a week, and see how that goes.
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  #13   ^
Old Wed, Jan-16-19, 18:06
doreen T's Avatar
doreen T doreen T is offline
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Just wanted to point out that the coffee study referenced in the OP was funded by Tchibo, a German coffee company. Also, the statistician who analyzed the data was appointed and paid by Tchibo.

from the abstract link .. https://link.springer.com/article/1...0394-018-1863-2
Quote:
Funding
This study has been supported by Tchibo GmbH, Hamburg, Germany.

......

Conflict of interest
D. Schipp is a self-employed statistician, who has been appointed and financed by Tchibo GmbH for this and other projects.

That being said .. Tchibo does make good coffee
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  #14   ^
Old Thu, Jan-17-19, 06:49
WereBear's Avatar
WereBear WereBear is offline
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Plan: Epi-Paleo/IF
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Had a persistent headache last night. Only thing different was the coffee so I guess thatís off the table for a while.

Also where do they get people who donít drink coffee! Do these folks differ in any other ways of significance?
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  #15   ^
Old Thu, Jan-17-19, 11:49
Meme#1's Avatar
Meme#1 Meme#1 is offline
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Plan: Atkins DANDR
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I never made coffee until my late 20s because my parents always drank that nasty Taster Choice instant coffee stuff. Now we buy whole beans by the 3 pound bag and grind it daily. It's so good and rich with heavy cream
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