Notdigestingsucroseishealthful : LC Research/Media Forum : Active Low-Carber Forums

#1 ^

Wed, Dec-29-21, 10:54

teaser

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Notdigestingsucroseishealthful

https://www.sciencedaily.com/releas...11222100818.htm

Quote:

For some Greenlanders, eating sugar is healthy

Quote:

Two copies of a gene variant make it so that they absorb sugar differently than other people do.

"Adult Greenlanders with the genetic variation have lower BMI, weight, fat percentage, cholesterol levels and are generally significantly healthier. They have less belly fat and might find it easier to get a six pack. It is amazing and surprising that a genetic variation has such a profoundly beneficial effect," says University of Copenhagen biology professor Anders Albrechtsen.

Along with colleagues from the University of Copenhagen, the University of Southern Denmark and a number of research institutions and public agencies in Greenland, Professor Albrechtsen analysed data from 6,551 adult Greenlanders and conducted experiments on mice.

The results demonstrate that carriers of the genetic variation have what is known as sucrase-isomaltase deficiency, meaning that they have a peculiar way of metabolizing sugar in the intestine. Simply put, they do not absorb ordinary sugar in the bloodstream the way people without the genetic variation do. Instead, sugar heads directly into their (large) intestine.

"Here, gut bacteria convert the sugar into a short-chain fatty acid called acetate, which in previous studies has been shown to reduce appetite, increase metabolism and boost the immune system. That is most likely the mechanism happening here," explains Mette K. Andersen, an assistant professor at the Center for Metabolism Research at the University of Copenhagen and first author of the study.

I added the word "large" in brackets. The wording still bugs me.

Of course this has the same problems as fructose malabsorption for the bowels if somebody eats too much of the sugars. And it wouldn't help somebody eating simple fructose--and you have to wonder how well people whose systems don't break down sucrose handle fructose itself.

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#2 ^

Thu, Dec-30-21, 06:20

Dodger Dodger is offline

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Acetate is a ketone body. So the health benefits are from being in ketosis.

Quote:

"Younger carriers of the variation experience negative consequences due to their different type of sugar absorption. For them, consuming sugar causes diarrhea, abdominal pain and bloating. Our guess is that as they age, their gut bacteria gradually get used to sugar and learn how to convert it into energy,"

Similar symptoms to eating too many sugar alcohols.

Quote:

"We can see that the genetic variation provides a better balance of fat in the bloodstream, which results in lower weight and consequently, fewer cardiovascular diseases. If you can develop a drug that inhibits the sucrase-isomaltase gene, then in principle, we might all be able to have equally strong health profiles," he concludes.

We don't need a new drug, we just need to greatly reduce carbs in our diet.

#3 ^

Thu, Dec-30-21, 07:32

GRB5111

Senior Member

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Quote:

Originally Posted by Dodger

Quote:

We don't need a new drug, we just need to greatly reduce carbs in our diet.

Interesting how the inferred role of fat in the bloodstream is deemed the cause of cardiovascular diseases in those without this variant. Once again, fat is to blame. However, I can also make a statement that people with this genetic variant handle sugar differently and aren't prone to those diseases defined by metabolic syndrome. In other words, it may be precisely because the typical impact of sugar to health is diminished in these people that they have "fewer cardiovascular diseases." And of course the other observation by the researcher that the treatment objective is to develop a drug to mimic the genetic variant rather than adjusting one's diet to eliminate sugar.