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  #1   ^
Old Wed, Jul-27-22, 05:22
WereBear's Avatar
WereBear WereBear is offline
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Plan: EpiPaleo/Primal/LowOx
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Default Exhausted? Might be mitochondrial

As someone trying to fix what medical science just wants to give me Ambien and Prozac for (it's the name of my new punk band) I am treasuring the work of Dr. Sarah Myhill.

She has a site with a wiki and many books. She's about healing the powerhouses of the cell, and the centerpiece of her treatment is the ketogenic diet.

One of her most helpful tips is the use of D-ribose. And even those of us on low carb might consider it. This is a shortcut to ATP for our cells, and I've noticed considerable improvement since adding some to my day.

It's a tub with a little scoop, and I've been shooting for 2-3 times a day. It hasn't changed my current weight. But it has been giving me more energy, which I try to direct towards healing by not doing much, anyway.

Early days. Must consolidate.

D-ribose Powder (1.5 tsp) contains 5g total carbs, 5g net carbs, 0g fat, 0g protein, and 20 calories. Which adds up to about how much many people eat in vegetable carbs, and I have very few of those
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  #2   ^
Old Wed, Jul-27-22, 07:23
Ms Arielle's Avatar
Ms Arielle Ms Arielle is online now
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Plan: atkins, carnivore 2023
Stats: 225/224/163 Female 5'8"
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Progress: 2%
Location: Massachusetts
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The mitochondria is a topic popping up.

It's our powerhouse. Apparently fasting also has a positive effect.

Looking forward to more information.
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  #3   ^
Old Mon, Aug-29-22, 05:25
WereBear's Avatar
WereBear WereBear is offline
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Plan: EpiPaleo/Primal/LowOx
Stats: 220/130/150 Female 67
BF:
Progress: 129%
Location: USA
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For DH, it's been a total game-changer, but that's because I found this site for his CFS/ME:

Dr Sarah Myhill

Who left the National Health service so she could treat these patients with methods that helped them: everything that has done dramatic good for DH's condition is due to such physicians, and she's a marvel.

She even has a test for mitochondrial exhaustion, but it's only local to her because she and another doctor invented it. But to diagnose oneself, it's when all lab tests have eliminated other organic possibilities. It's really a post-viral syndrome, which can be triggered by ANY virus, so chasing THE virus was a serious misstep.

Now that Long COVID is a thing, we might get some recognition of her work, which treats cell exhaustion, and if a lightbulb just went on: yeah. That fundamental.

She has books on Amazon in the US. DH prefers audiobooks, but he was so impressed he immediately agreed we should put her plan into action. He's been stepping down into the diet and once he hit the full commitment level, his improvement got much faster.

It's designed to be ketogenic. And he'd seen the same thing work for me, but he can't turn on a dime that way.

So we are getting a tidier fridge, too. Nothing is going to keep! Eat it or feed the wildlife!

But we all know it's not easy... until it is.

Clarity edit: DH has been dealing with this disability level issue for longer than our marriage, which turned 21 (ready for a beverage!) recently. So he's been through the weird stuff that didn't work, though I helped him discover weird things that did work. I found the site, but he plunged into it and worked out his own routine. I consult

Last edited by WereBear : Mon, Aug-29-22 at 05:30.
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  #4   ^
Old Thu, Sep-07-23, 18:23
Ms Arielle's Avatar
Ms Arielle Ms Arielle is online now
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Plan: atkins, carnivore 2023
Stats: 225/224/163 Female 5'8"
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Progress: 2%
Location: Massachusetts
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How has this been working out for u and DH?? Looking for update.

Im seeing TONS by a wide variety of online doctors on mitochondria. What I like is that we do have a say in mitochondrial health. We just have to do it.
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  #5   ^
Old Fri, Sep-08-23, 06:49
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WereBear WereBear is offline
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Plan: EpiPaleo/Primal/LowOx
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Hi Ms. Arielle!

DH and I are both on Benfotiamine, a well-absorbed form which is fat-soluble and gets where it needs to go. Since my experience with high doses of niacin have been so positive, I take double the dose on the bottle.

As a nod to the rule which says "You need ALL your Bs" I take a good quality B complex, too. Along with a high protein, low oxalate diet, I'm seeing real improvement from him. His dizzy spells, which makes him use a cane, has improved. He's lost a lot of weight and weaning off his blood pressure meds.

We both have stellar A1C scores, which is first and foremost about metabolism. He's dealing with a Long Viral Syndrome and I'm trying to get out of Burnout, but our routines mostly intersect.

We're not THAT low carb because I don't think our metabolism is up for it. They need the cheap energy of certain selected carbs. Still seems to be working.
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  #6   ^
Old Fri, Sep-08-23, 08:11
Ms Arielle's Avatar
Ms Arielle Ms Arielle is online now
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Posts: 19,301
 
Plan: atkins, carnivore 2023
Stats: 225/224/163 Female 5'8"
BF:
Progress: 2%
Location: Massachusetts
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Great news. Progress. Dizziness is rather debilitating . Effects all movement...who wants to stand up and move if dizziness hits and risk of falling is real.

I too take a B complex. I dont trust our food sources to supply all our nutrients..foods its for weeks or months in storage before hitting the grocery shelves.

Benfotiamine is on my to buy list. For now just taking the B complex pill.

Hba1c is good indicator of how well your diet is working for you, even if not low carb. Imho, use what ever diet the body needs to keep a1c down to 5.0 or lower.

Sounds like you are continuing to heal....
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  #7   ^
Old Sat, Sep-09-23, 05:58
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WereBear WereBear is offline
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Plan: EpiPaleo/Primal/LowOx
Stats: 220/130/150 Female 67
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Quote:
Originally Posted by Ms Arielle
Sounds like you are continuing to heal....


I am! I went kayaking. Though of course that was not smooth. Pre-Pandemic, I had put a chain and lock on our two kayaks, and in the interim, lost both keys. Since memory was one of the things that "went," though it is coming back too!

My aunt was here for a visit but bolt cutters didn't work. And she's a strong and healthy person. So I borrowed a friend's kayak, as had been previously arranged, and I didn't know it was a racing kayak. So this thing wanted to do 360s constantly, and I let it, because it rode low and too much body english and I'd lose buoyancy.

Aunt was using the kayak that came with her rental on the lake, so we had a great time and I left her at her motel (they are nice where I am) so I paddled home alone and found the kayak fit like a wetsuit. And my friend is about 5 inches shorter. And I'd lost my sandals somewhere in it, so I would have to maneuver, barefooted.

As I hung on the dock with one elbow, pondering this logic puzzle, along came two ladies paddling inflatable kayaks, who helped me pin mine against a breakwater as I hauled myself up and out. It turned into down and out, but the kayak and I were both fine, found my sandals in it, and hauled the kayak next door to its home.

And I managed all this without fatigue or anxiety. I have definitely reached a better plateau of health. My low carb and Carnivore efforts laid the foundation, and low oxalate has really let me build on it. And contributed to my continuing efforts to recover from neurodivergent burnout. Which does take years, even without a global emergency of long duration.

People ask what happened to me, and I explain, "The last few years have not been a good time to have a stress-related illness." They certainly get that

Six months and my face (small but painful lesions at the corners of my eyes and mouth) is finally healing. I'm convinced that autoimmune and oxalate poisoning are almost identical. Both misunderstood by modern medicine. Both manifesting in different ways in each person. Both bringing serious consequences.

A wonderful friend of mine was a transplant patient, and when a person signs up for the autoimmune drugs, they are essentially in the same leaky boat. They eventually died from an uncontrolled infection, after suffering from it considerably.

It was scary. My own visible illness covers less than 5% of my skin, and is considered MILD. Except for my one big flare (and I never want another!) because it's more like lupus in the fatigue and pain. So even getting a diagnosis past excema and psoriasis would be a struggle.

And the consequences for misdiagnosis in this field are grim. I read a memoir by a woman who drifted more and more vegan "for health" until she had scary symptoms and a lesion was found on her spine with an MRI. She was told she "had MS, pick a drug, none of them work very well," by the nationally famous specialist in her state. And that was the end of her care.

After several attempts, she discovered she was B-12 deficient, which fixed everything. But now there is no way to show she was misdiagnosed, no way to show she is well, since MS spontaneously remits, and the diagnosis means her health insurance was affected, until the law was changed.

She also fears that any visit could declare that "the MS is back" and her symptoms will be attributed to the wrong thing.

Always, with my own struggles with autoimmune, I become more firmly convinced that medical science knows what it does, but nothing else. And their help actually makes people worse.
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  #8   ^
Old Wed, Sep-20-23, 23:44
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Demi Demi is offline
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Plan: Muscle Centric
Stats: 238/153/160 Female 5'10"
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I thought this Wahls Protocol Wellness Workshop might be of interest here:

Quote:
Targeting Mitochondrial Health: An Advanced Nutrition Strategy For Healthy Aging

September 29, 2023 12:00-1:00 pm CT

Join Dr. Anurag Singh, MD PhD, the Chief Medical Officer at Timeline, and me for a lecture to explore the connection between mitochondrial dysfunction and the development of various age-related chronic conditions.

Dr. Singh will analyze the evidence supporting interventions aimed at enhancing mitochondrial function and their impact on overall aging trajectories. Plus he will evaluate the latest scientific insights into the impact of Urolithin A, a novel nutritional compound, on mitochondrial health and function.

https://terrywahls.com/wellness-wor...iartFr3VXH0yRJU


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  #9   ^
Old Sat, Sep-23-23, 06:01
WereBear's Avatar
WereBear WereBear is offline
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Posts: 14,781
 
Plan: EpiPaleo/Primal/LowOx
Stats: 220/130/150 Female 67
BF:
Progress: 129%
Location: USA
Default

There has been a burst of new research from long COVID, which is actually Long Viral Syndrome, baffling doctors since at least the 1950s. Then again, it used to be referred to as his "health broke" and there was plenty in the industrial past that would sneak up and get one that way, I'm sure.

I'm on benfotiamine as a result of the mitochondrial research, and I'm glad to see Dr. Wahls still involved with the latest. Still, to be honest, I don't like hearing about amazing new supplements when benfotiamine has been around since the early 2000's and was promising for diabetes research. I wonder why it was ever dropped, she said darkly.

But now I am hearing about it which is why I wonder about the Wahls connection with such. Apparently:

Quote:
Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. Feb 2, 2021 Science Direct


Which shows she is still very plant heavy in her approach, though at least it sounds she has moved to keto, I know she has done personally. I'm sure the research supports this, but keto also has its pitfalls.

The polyphenols get talked up a lot as an antioxidant, but it's theoretical. And contradicts my own experience! So I'm torn.

I was turned off the Wahls protocol diet, but everything else in her book was sound and gave me a lot of insight.
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  #10   ^
Old Wed, Oct-18-23, 05:00
WereBear's Avatar
WereBear WereBear is offline
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Posts: 14,781
 
Plan: EpiPaleo/Primal/LowOx
Stats: 220/130/150 Female 67
BF:
Progress: 129%
Location: USA
Default

Behold, the B1 protocol for treating Parkinson's.

Quote:
This section describes the High-Dose Thiamine (B1) Therapy Protocol developed and used by Dr Costantini for persons with Parkinson’s Disease.
D. Bryan provides the key aspects of The Protocol in her book on “Parkinson’s and the B1 Therapy”.

The B1 Protocol section:
Explains some of the major challenges of implementing the Protocol, namely the approach to identifying the right dose;
Highlights the Protocol main elements;
Looks at the advantages and disadvantages of different routes of administration; and
Provides information on many tools which have been developed for self-monitoring.


https://b1parkinsons.org/about-the-b1-protocol

That's all I know, since I embarked on the thiamine therapy and I can tell it's working, but I have stretches with little energy (which is normal!) and I want to look into it more.

This actually supports Dr. Wahls' contention that all autoimmune is ONE disease, manifesting in different ways in different people, through the routes of their genetic and environmental switches. I think that is a fantastic insight.

But the latest copy of her book advises people to eat a boatload of health vegetables, much like Dr. Atkins does in all of his books.

Personally, I agree that we should recognize that plants are trying to kill us. What 19th century chemistry recognized as nutrients had to wait for 20th century biology to show us how it all worked.

Plants are addicting. Animal foods aren't. I think that's all we need to know.
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