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Old Fri, May-30-08, 23:52
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Elihnig Elihnig is offline
Don't dream it be it
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Plan: Low Carb
Stats: 292.4/272.0/165 Female 70 inches
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Location: Maine
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Ron Rosedale, 1999

Quote:
Ron Rosedale, M.D.
Insulin and It's Metabolic Effects
Presented at Crayhon Research Institute's BoulderFest August 1999 Seminar
Let's talk about a couple of case histories. These are actual patients that I've
seen; let's start with patient A. This patient who we will just call patient A saw me
one afternoon and said that he had literally just signed himself out of the hospital
"AMA," or against medical advice. Like in the movies, he had ripped out his IV's. The
next day he was scheduled to have his second by-pass surgery. He had been told
that if he did not follow through with this by-pass surgery, within two weeks he
would be dead. He couldn't walk from the car to the office without severe chest pain.
He was on 102 units of insulin and his blood sugars were 300 plus. He was on eight
different medications for various things. But his first by-pass surgery was such a
miserable experience he said he would rather just die than have to go through the
second one and had heard that I might be able to prevent that. To make a long story
short, this gentleman right now is on no insulin. I first saw him three and a half
years ago. He plays golf four or five times a week. He is on no medications
whatsoever, he has no chest pain, and he has not had any surgery. He started an
organization called "Heart Support of America" to educated people that there are
alternatives to by-pass surgery that have nothing to do with surgery or medication.
That organization, he last told me had a mailing list of over a million people, a large
organization, "Heart Support of America."
Patient B is a patient who had a triglyceride level of 2200. Patient B was
referred by patient A. He had a triglyceride of 2200, cholesterol of 950 and was on
maximum doses of all of his medications. He was 42 years old, and he was told that
he had familial hyperlipidema and that he had better get his affairs in order, that if
that was what his lipids were despite the best medications with the highest doses, he
was in trouble. He was not fat at all, he was fairly thin. Whenever I see a patient on
any of those medications, they're off the very first visit. They have no place in
medicine. He was taken off the medications and in six weeks his lipid levels, both his
Triglycerides and his cholesterol were hovering around 220. Six more weeks they
were both under 200, off of the medications. They have no place in medicine. I
should mention that this patient had a CPK that was quite elevated. It was circled on
the lab report that he brought in initially with a question mark by it because they
didn't know why. The reason why was because he was eating off his muscles,
because if you take (gyinfibrozole) and any of the HMG co-enzyme reductase
inhibitors together, that is a common side effect that is in the PDR, and they
shouldn't be given together. So he was chewing up his muscles, including his heart
which they were trying to treat. So if indeed he was going to die, it was going to be
that treatment that was going to kill him.
Let's go to something totally different, a lady with severe osteoporosis. She is
almost three standard deviations below the norm in both the hip femeral neck and
the cervical vertebrae, and she is very worried about getting a fracture. A fairly
young woman and she was put on a high carbohydrate diet and told that would be of
benefit, and placed on estrogen, which is a fairly typical treatment. They wanted to
put her on some other medicines and she didn't want to, she wanted to know if there
was an alternative. Although we didn't have as dramatic a turn around, we got her to
one standard deviation below the norm in a year, taking her off the estrogen she was
on, anyway.
Let's go to calaudication. That is severe angina of the leg when you walk, same
thing as angina of the heart except of the leg. While walking, after walking a certain
distance, there is pain. There was a gentleman who had extremely severe
calaudication, who happens to be my stepfather. It was a typical case, he would walk
about fifty yards and then he would get severe, crampy pain in his legs. He was quite
well off and was going to see the best doctors in Chicago, and they couldn't figure
out what was wrong with him initially. He went to a neurologist, they thought it
might be neurological pain or back pain. He finally went to a vascular surgeon who
said he thought it was vascular disease, so they did an artheriogram and sure
enough, he had severe vascular disease. They did Doppler studies on his ankobracheal
ratio on one side and it was 0.6, normal is around 1.1. 0.4 and you are in
trouble for gangrene, so it was pretty bad, and they wanted to do the typical by-pass
surgery that they normally do on this. He was thinking of going in for the surgery for
one reason, they had a trip planned to Europe in two weeks, and he wanted to be
able to walk since they normally do a lot of walking. Ten years previously he'd had
an angioplasty for heart disease. At the time ten years ago, I told him he had to
change his diet and he didn't of course. But this time he listened. I said that if he
was not going to have a by-pass, then do exactly what I tell you to do and in two
weeks you'll be walking just fine because by modulating this one aspect of his
disease, I have never seen it not work, and it works very quickly to open up the
artery.
We can talk about a patient with a very high cancer risk. She had a mother and
a sister who both died of breast cancer and she didn't want to, so she came in and I
put her on the exact same treatment as the other cases I just mentioned. They were
all treated virtually identically because they all had the same thing wrong with them.
What would be the typical treatment of cardiovascular disease? First they check the
cholesterol. High cholesterol over 200, they put you on cholesterol lowering drugs
and what does it do? It shuts off your CoQ10. What does CoQ10 do? It is involved in
the energy production and protection of little energy furnaces in every cell, so energy
production goes way down. A common side effect of people who are on all these
HMG co-enzyme reductase inhibitors is that they tell you their arms feel heavy. Well,
the heart is a muscle too, and it's going to feel heavy too. One of the best
treatments for a weak heart is CoQ10 for congestive heart failure. But they have no
trouble shutting CoQ10 production off so that they can treat a number. And the
common therapies for osteoporosis are drugs, and the common therapy for
calaudication is surgery. For cancer reduction there is nothing. But all of these have
a common cause.
The same cause as three major avenues of research in aging. One is called caloric
restriction. There are thousands of studies done since the fifties on caloric restriction.
They restrict calories of laboratory animals. They have known since the fifties that if
you restrict calories but maintain a high level of nutrition, called "C.R.O.N.'s:" Caloric
restriction with optimal nutrition, or adequate nutrition, which would be CRAN"S,
these animals can live anywhere between thirty and two-hundred percent longer
depending on the species. They've done it on several dozen species and the results
are uniform throughout. They are doing it on primates now and it is working with
primates, we won't know for sure for about another ten years, they are about half
way through the experiment, our nearest relatives are also living much longer.
Then there are Centenarian studies. There are three major centenarian studies going
on around the world. They are trying to find the variable that would confer longevity
among these people. Why do centenarians become centenarians? Why are they so
lucky? Is it because they have low cholesterol, exercise a lot, live a healthy, clean
life? Well the longest recorded known person who has ever lived, Jean Calumet of
France who died last year at 122 years, smoked all of her life and drank. What they
are finding on these major centenarian studies is that there is hardly anything in
common among them. They have high cholesterol and low cholesterol, some
exercise and some don't, some smoke, some don't. Some are nasty as can be and
some nice and calm and nice. Some are ornery, but they all low sugar, relatively for
their age. They all have low triglycerides for their age. And they all have relatively
low insulin. Insulin is the common denominator in everything I've just talked about.
They way to treat cardiovascular disease and the way I treated my stepfather, the
way I treated the high risk cancer patient, and osteoporosis, high blood pressure, the
way to treat virtually all the so-called chronic diseases of aging is to treat insulin
itself.
The other major avenue of research in aging has to do with genetic studies of socalled
lower organisms. We know the genetics involved. We've got the entire genes
mapped out of several species now, of yeast and worms. We think of life span as
being fixed, sort of. Humans kind of have an average life span of seventy-six, and
the maximum life-span was this French lady at one-hundred and twenty-two. In
humans we feel it is relatively fixed, but in lower forms of life it is very plastic. Life
span is strictly a variable depending on the environment. They can live two weeks,
two years, or sometimes twenty years depending on what they want themselves to
do, which depends very much on the environment. If there is a lot of food around
they are going to reproduce quickly and die quickly, if not they will just bide their
time until conditions are better. We know now that the variability in life span is
regulated by insulin.
One thinks of insulin as strictly to lower blood sugar. Today in the clinic there was a
patient listing off her drugs, she listed about eight drugs she was on and didn't even
mention insulin. Insulin is not treated as a drug. In fact, in some places you don't
even need a prescription, you can just get it over the counter, it's treated like candy.
Insulin is found as in even single celled organisms. It has been around for several
billion years. And its purpose in some organisms is to regulate life span. The way
genetics works is that genes are not replaced, they are built upon. We have the
same genes as everything that came before us. We just have more of them. We
have added books to our genetic library, but our base is the same. What we are
finding is that we can use insulin to regulate lifespan too.
If there is a single marker for lifespan, as they are finding in the centenarian studies,
it is insulin, specifically, insulin sensitivity. How sensitive are your cells to insulin.
When they are not sensitive, the insulin levels go up. Who has heard of the term
insulin resistance? Insulin resistance is the basis of all of the chronic diseases of
aging, because the disease itself is actually aging. We know now that aging is a
disease. The other case studies that I mentioned, cardiovascular disease,
osteoporosis, obesity, diabetes, cancer, all the so-called chronic diseases of aging,
auto-immune diseases, those are symptoms. If you have a cold and you go to the
doctor, you have a runny nose, I did Ear, Nose and Throat for ten years, I know
what the common treatment for that is, they give you a decongestant. I can't tell
you how many patients I saw who had been given Sudafed by their family doctors
for a cold and they came to see me after because of a really bad sinus infection.
What happens when you treat the symptom of a runny nose from a cold and you
take a decongestant? It certainly decongests you by shutting off the mucus. Why do
you have the mucus, because you are trying to clean and wash out the membranes,
and what else? What else is in mucus? Secretory IgA, a very strong antibody to kill
the virus is in the mucus. If there is no mucus, there is no secretory IgA.
Decongestants also constrict blood vessels, the little capillaries, or arterioles that go
to those capillaries, the cilia, the little hair-like projections that beat to push mucus
along to create a stream, they get paralyzed because they don't have blood flow so
there is no more ciliary movement. What happens if you dam a stream and create a
pond? In days you've got larvae growing. If the stream is moving, you are fine. You
need a constant stream of mucus to get rid of and prevent an infection. I am going
in to this in some detail because in almost all cases if you treat a symptom, you are
going to make the disease worse because the symptom is there as your body's



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