I took Statins about 20 years ago and ever since my calves have been very tight and at times painful. I tried about everything to resolve it, COQ-10, Magnesium, and many other combinations with out success. No, I just tell doctor NO emphatically and tell them the background and they don't usually ask me again until the following year, it seems they have to ask every year. Because of my experience, there is no way I will EVER take statins again.