Know what brings leptin down? Successful weight loss. Know what brings it back up? Storing fat. You can bring leptin up with carbs. You could do the same thing by overeating (maybe it would have to be a force feeding experiment) an Atkins type diet.

Left out of this is that most overweight people probably have high leptin to start with.

https://www.physiology.org/na101/ho...d10221001x.jpeg

I was going to post this image directly, but it comes in enormous. Plasma leptin in obese women at 22 hours is 90 percent of what it is at 14 hours. In lean women, it looks like around 42 percent. Adipose tissue leptin production also decreases more in lean than in obese women. Absolute leptin production is also higher in the obese women at all time points. If you are obese or overweight, and eating carbs to keep your leptin up, you or your advisors are simply working from the wrong data. Even in lean people, I think carbs for leptin is a bit delusional, unless it's a lean person who's underweight. I'm not saying there aren't people who can get leaner on a carby diet, I'm saying I doubt it's because it fixes the leptin.

https://www.physiology.org/doi/10.1...2000.278.2.E280

Underweight, on a weight loss diet whether low carb or not? Leptin likely ties into fertility, loss of libido etc. Overweight with PCOS? This probably helps to explain the opposite, normalization of leptin with weight loss, increased leptin sensitivity, better overall hormone profile.