I've been using natural progesterone for the last 4 months. My hot flashes disappeared, no more crazy mood swings, and I'm sleeping better than ever. (My progesterone and estrogen are quite low.)

I don't know that I would use it on my thighs or abdomen though. Dr. Lee (What You Doctor May NOT tell you about Premenopause) says the best places are on the neck/throat, inner arms, and behind the knees, if memory serves me correctly. It needs to go places where the skin is thinner and uncalloused. Putting it where we have the most fat causes it to absorb into the bloodstream too slowly. I believe at one point Dr. Lee said abdomen and thighs, but then changed his stance on it later.