In response to die off symptoms that are flu like, yes that is what is happening. I was under doctors care taking nystatin 9 pills at a time and had massive die off. I was sick with headaches, very upset stomach, and pain in all parts of my body for over 14 days. I could not work, eat or sleep. On the other side of it I never felt so good. He told me I had never been well so would not know how great I would feel. He was right and it was worth every sick day to get to the other side! Energy id awesome and my thinking has cleared up dramatically. Can't even have a negative thought. I now take Yeast Defense to keep things under control every day!