View Single Post
  #351   ^
Old Thu, Apr-29-21, 13:34
JEY100's Avatar
JEY100 JEY100 is offline
Posts: 13,370
 
Plan: P:E/DDF
Stats: 225/150/169 Female 5' 9"
BF:45%/28%/25%
Progress: 134%
Location: NC
Default

New report in The Lancet:

Quote:
At a BMI of more than 23 kg/m2, we found a linear increase in risk of severe COVID-19 leading to admission to hospital and death, and a linear increase in admission to an ICU across the whole BMI range, which is not attributable to excess risks of related diseases. The relative risk due to increasing BMI is particularly notable people younger than 40 years and of Black ethnicity."


23 BMI !. A "healthy" BMI of 25 is a bridge too far for many in the US. I haven't dug into these numbers and unlikely I will ever be able to understand the statistical modeling done. But always impressed by the size and range of UK observational data when they have access to NHS records. Almost 7 million in the data set.

https://www.thelancet.com/journals/...J1swJYK1 i5OmA

The report addresses the genetic tendency for Asians to have metabolic disease/T2 at lower BMIs.

Quote:
Male sex, Black and Asian ethnicity, and type 2 diabetes have been found to be associated with an increased risk of adverse outcomes from severe SARS-CoV-2 infection.7, 8, 9, 10, 11 One factor that links these groups is a tendency to store fat in the abdominal region (visceral fat) and also in tissues other than adipose tissue, such as the liver, heart, or skeletal muscle (ie, ectopic fat).21 Three small studies of patients admitted to hospital due to COVID-19 have found that a tendency for visceral fat accumulation, measured using CT, was independently associated with adverse COVID-19-related outcomes.22, 23, 24 The risk of severe COVID-19 outcomes attributable to excess weight (ie, ≥23 kg/m2) has been proposed to be a consequence of metabolic impairment of organ functioning, leading to insulin resistance.25 We found little evidence of a difference in the association between BMI and severe COVID-19 outcomes in people with and without type 2 diabetes (a condition strongly associated with accumulation of ectopic fat) to support this hypothesis. In fact, we found that people with type 2 diabetes were at lower risk of severe COVID-19 outcomes per unit increase in BMI than those without type 2 diabetes. People with type 2 diabetes are only a subset of people with increased likelihood of ectopic fat deposition. Central fat accumulation could contribute to the increased risk associated with unit increase in BMI in the younger age group, since previous reports suggest a disproportionate increase in waist circumference relative to BMI among English adults.26 Direct measurements of ectopic fat, or proxy measures such as waist circumference, are rarely done in routine care and accurate data were not available for our analysis so we were unable to test this hypothesis, as was originally specified in our protocol.
Reply With Quote