Thu, Jun-26-08, 17:12
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Senior Member
Posts: 1,162
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Plan: Atkins
Stats: 228/195/188
BF:
Progress: 83%
Location: Erie PA
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"But the conclusion drawn..."
"the conclusion they derived..."
There is no conclusion section in this study. Only a discussion, in which they present their findings. You're left to draw your own conclusions. The media is quick to draw conclusions, and those who have an ax to grind. They refer to previous studies, both positive and negative, as a reason to do another (this) study.
Quote:
Discussion
We conducted this study because previous clinical trials had not established the effects of intensive glucose lowering on cardiovascular events or mortality in patients with type 2 diabetes mellitus. For example, in the United Kingdom Prospective Diabetes Study,15 an intensive glucose-lowering regimen significantly reduced a composite outcome of seven diabetes-related events, as compared with conventional therapy. However, the effects on cardiovascular events and mortality were not significant. Conversely, in the Veterans Affairs Diabetes Feasibility Trial,16 intensive glucose lowering was associated with a nonsignificant increase in cardiovascular events and no difference in mortality, and in the University Group Diabetes Program,17,18 the group that received a sulfonylurea (tolbutamide) had higher mortality.
Our findings indicate that a comprehensive, customized, therapeutic strategy targeting glycated hemoglobin levels below 6.0% increased the rate of death from any cause after a mean of 3.5 years, as compared with a strategy targeting levels of 7.0 to 7.9% in patients with a median glycated hemoglobin level of 8.1% and either previous cardiovascular events or multiple cardiovascular risk factors. Patients in both groups had lower mortality than reported in epidemiologic studies of similar patients.19,20 However, as compared with the standard-therapy group, the intensive-therapy group had a relative increase in mortality of 22% and an absolute increase of 1.0% during this follow-up period, with similar differences in death from cardiovascular causes. This increase in mortality is equivalent to one extra death for every 95 patients who were treated for 3.5 years.
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