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I wish I were an expert in this field, it's very interesting to me --especially the cancer implications. But this is how I think the process works in LCers like us:

If you inhibit glycolytic enzymes I doubt that means you stop them completely, probably just slow them down a little. But tumor cells only get a net of 2 ATPs per molecule of glucose from glycolysis so they're cycling those enzymes as fast as possible, and generating a ton of pyruvate (which is immediately transformed into lactic acid which diffuses out of the cell and becomes glucose again in the liver). So slowing the enzymes down even a little could have a big effect on total ATP generation per minute in the tumor cell.

A normal cell with slow glycolysis enzymes would still produce a lot of pyruvate which would enter normal mitochondria and be transformed into 36 more ATPs per glucose, so they'd still get the full energy complement from the available glucose.

Maybe we could run this past Dr. E...