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Old Thu, Dec-27-18, 16:18
M Levac M Levac is offline
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Posts: 6,495
Plan: VLC, mostly meat
Stats: 202/200/165 Male 5' 7"
Progress: 5%
Location: Montreal, Quebec, Canada

Intermittent fasting is one of the most effective dietary restriction regimens that extend life span in C. elegans and mammals.

Glucose restriction is very effective in C. elegans. In mammals, neither IF nor glucose restriction (i.e. low-carb) is conclusive with regards to longevity. The most prominent effect is on overall health. And here, low-carb works best.

OK, so the premise is some form of restriction to increase lifespan. In a mechanical sense, this makes sense. The less often we use a machine (or the less stress for a continuously running machine), the longer it remains functional. In a biological sense, it doesn't. To wit, chaperone-mediate autophagy, whereby an energy substrate - ketones - stimulate clean-up of what would otherwise decrease lifespan. The more ketones, the less crud, the longer lifespan. Or at least, if lifespan was a function of crud. It's not. Health is a function of crud.

OK, so the premise isn't just lifespan, it's up-to-maximum lifespan. What controls maximum lifespan? As far as anybody knows, we don't know. Whatever these experts are looking at ain't it, cuz it's all about health - up-to-maximum lifespan - not about absolute lifespan.
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