From Robb Wolf's The Paleo Solution

"Fructose preferentially fills liver glycogen...eating fructose increases the amount of glucose the liver absorbs. Fructose up-regulates the glucose transport molecule in the liver, making the liver 'hungry' for sugar."

I always assumed HFCS got the moniker "high fructose" because it had more fructose than regular sugar. No matter how you slice it, it's all bad for you. More fructose means more bad (pardon my English), but pick your poison.

I guess if the fructose isn't necessarily higher in HFCS than it is in sugar than, well sure, HFCS isn't necessarily worse for you than sugar. 42% - 90% sure is a big spread, though.