Well, I'm surprised that there hasn't been more research on this subject b/c reading these posts, it appears that I am not the only one with an intolerance for alcohol with hypothyroidism/Hashimoto Disease. My husband now calls me "Me, Myself and Irene" when I have anything to drink. Been on synthroid for a year now just recently had my dose upped to 1 mcg daily. Glad to know I'm not crazy.