Tue, Apr-10-18, 04:34
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Plan: P:E/DDF
Stats: 225/150/169
BF:45%/28%/25%
Progress: 134%
Location: NC
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Statins and ALS
New study, and brilliant analysis of risk by Dr Malcolm Kendrick.
https://drmalcolmkendrick.org/2018/...eral-sclerosis/
Please read all of the article at link, as it has risk charts and odds ratios by different statins types hard to copy. But here is one excerpt,
Quote:
The two most widely prescribed statins are simvastatin and atorvastatin. Atorvastatin increases risk seventeen fold, and simvastatin twenty three fold.
It is often said that association does not mean causation. However, this is only true up to a point. Most statisticians agree that an odds ratio > 6 represents proof of causation. When you find that people taking atorvastatin have a seventeen-fold increase in risk of ALS, this is proof of causation. The effect is too massive to be due to anything else.
So, what does all this mean in the real world. Well around two to three people per 100,000 develop ALS every year (call this 2.5/100,000). If you increase this seventeen-fold, then around forty more people will develop ALS every year, per 100,000.
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