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Old Sat, Nov-21-20, 10:59
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Default Diabetes drug versus heart failure

Sort of a weird one here...

Empagliflozin, a recently developed diabetes drug, can effectively treat and reverse heart failure in both diabetic and non-diabetic patients, according to researchers at the Icahn School of Medicine at Mount Sinai.

That sounded familiar, I wondered about mechanism of action.

Empagliflozin is an inhibitor of the sodium glucose co-transporter-2 (SGLT-2), which is found almost exclusively in the proximal tubules of nephronic components in the kidneys. SGLT-2 accounts for about 90 percent of glucose reabsorption into the blood. Blocking SGLT-2 reduces blood glucose by blocking glucose reabsorption in the kidney and thereby excreting glucose (i.e., blood sugar) via the urine.[29][30][31]

Wikipedia on the drug.

So that's why it's familiar, we've talked about this on the Dr. Fung thread.

Roughly 80 percent of the patients treated with empagliflozin showed significant improvement, and their hearts returned to near normal, the researchers found. This group had a 16.6 percent improvement in left ventricular ejection fraction at the six-month mark and their hearts pumped blood in a stronger way. Their hearts became smaller, less dilated because of less congestion and less fluid accumulation in the body, meaning that their heart failure became less severe, and the walls of the heart were less thick, meaning that the left ventricle could pump blood more easily.

Sounds a little weird but then you go okay, kidney controls blood and plasma volume and content, electrolytes, glucose etc. The blood that's pumped through is a major part of the environment that heart cells are exposed to--and environmental stressors are a major factor in determining the modeling of various organs in the body. Besides that--they're constantly finding ways that various organs "communicate," there might be nervous system and hormonal signalling passing one way or another between the kidney, (or even the liver since lowering blood sugar in this particular way will have consequences to its metabolism as well) and the heart.
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