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Quote:

The keto diet can actually increase a person's lifespan by making their cells more resistant, a new study finds

Researchers at Stanford University found that the diet provides similar resiliency to body cells that fasting does

The diet is very low carb, and instead replace them with fats to serve as the body's primary energy source

https://www.dailymail.co.uk/health/...tudy-finds.html

Quote:

Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling

DOI:https://doi.org/10.1016/j.cmet.2022.04.012

Short-term fasting is beneficial for the regeneration of multiple tissue types. However, the effects of fasting on muscle regeneration are largely unknown. Here, we report that fasting slows muscle repair both immediately after the conclusion of fasting as well as after multiple days of refeeding. We show that ketosis, either endogenously produced during fasting or a ketogenic diet or exogenously administered, promotes a deep quiescent state in muscle stem cells (MuSCs). Although deep quiescent MuSCs are less poised to activate, slowing muscle regeneration, they have markedly improved survival when facing sources of cellular stress. Furthermore, we show that ketone bodies, specifically β-hydroxybutyrate, directly promote MuSC deep quiescence via a nonmetabolic mechanism. We show that β-hydroxybutyrate functions as an HDAC inhibitor within MuSCs, leading to acetylation and activation of an HDAC1 target protein p53. Finally, we demonstrate that p53 activation contributes to the deep quiescence and enhanced resilience observed during fasting.

https://www.cell.com/cell-metabolis...4131(22)00182-6