Sun, Oct-11-20, 15:15
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Senior Member
Posts: 7,582
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Plan: EF/Fung IDM/keto
Stats: 375/225.4/175
BF:
Progress: 75%
Location: NE Florida
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Quote:
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Originally Posted by JEY100
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Interesting quote from the article about a certain study:
Quote:
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“I’m as excited as anyone about vitamin D, but I’m not ready to jump on the bandwagon,” says Mark Moyad, MD, the Jenkins/Pokempner director of preventive and alternative medicine at the University of Michigan Medical Center....To illustrate his point, he describes the decades of promising research that linked low vitamin D levels to bone weakness. But when, for a 2019 JAMA study, people took high daily doses of vitamin D for three years, their bones actually got weaker, not stronger. While the known risks of taking moderate amounts of vitamin D as a supplement are minimal, the JAMA study’s findings — as well as the findings of many other past vitamin studies — show that there can be unexpected and often unwanted consequences associated with supplement use.
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This is the study it references:
https://jamanetwork.com/journals/ja...article/2748796
It sounds like a pretty well-designed randomized study of older adults (55-70).
Quote:
This 3-year randomized clinical trial examined the effect of 3 daily doses of vitamin D: 400 IU, 4000 IU (the National Academy of Medicine [formerly the Institute of Medicine {IOM}] tolerable upper intake level), and 10 000 IU in healthy adults aged 55 to 70 years and failed to find a positive effect of vitamin D on volumetric BMD and estimated bone strength, as measured by HR-pQCT at the radius and tibia.
Instead of the hypothesized increase, a negative dose-response relationship was observed for volumetric BMD. Using the 400-IU group as a reference point, high-dose vitamin D supplementation (10 000 IU/d) was associated with a significantly greater loss of bone.
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Maybe it's studies like this one that have led some of the folks I enjoy following to say higher levels of D3 are not necessarily better. However there was no placebo group in the study, and people who had very low levels of D initially were excluded. Though this study concentrated on bone health as opposed to other possible benefits of D3 supplementation. Interesting read however. |