Ok after reading JL53563 experiment I needed to research how the body digest fats... I found the following explanation
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Quote:
Fat Breakdown In The Small Intestine
Fat digestion and absorption requires that the complex fat molecules be broken down into smaller more manageable molecules. This is done by mixing the fat with the digestive enzyme lipase, which enters the duodenum from the pancreas - the main source of enzymes for digesting fats and proteins. Lipase chops up lipid molecules into fatty acid molecules and glycerol molecules. However, because fat does not dissolve in water, the fat molecules enter the duodenum in a congealed mass, which makes it impossible for the pancreatic lipase enzymes to attack them, since lipase is a water soluble enzyme and can only attack the surface of the fat molecules. To overcome this problem the digestive system uses a substance called bile, produced in the liver but stored in the gallbladder, which enters the duodenum via the bile duct. Bile emulsifies fats - meaning, it disperses them into small droplets which then become suspended in the watery contents of the digestive tract. Emulsification allows lipase to gain easier access to the fat molecules and thus accelerates their breakdown and digestion.
How Fat Is Digested And Absorbed Into The Bloodstream
Lipase and other digestive juices break down the fat molecules into fatty acids and types of glycerol. Absorption of fat into the body, which takes 10-15 minutes, occurs in the villi - the millions of finger-like projections which cover the walls of the small intestine. Inside each villus is a series of lymph vessels (lacteals) and blood vessels (capillaries). The lacteals absorb the fatty acids and glycerol into the lymphatic system which eventually drains into the bloodstream. The fatty acids are transported via the bloodstream to the membranes of adipose cells or muscle cells, where they are either stored or oxidized for energy. Since glucose rather than fat is the body's preferred source of energy, and since only about 5 percent of absorbed fat (the glycerols) can be converted into glucose, a significant proportion of digested fat is typically stored as body fat in the adipose cells. The glycerol part is absorbed by the liver and is either converted into glucose (gluconeogenesis), and/or used to help breakdown glucose into energy (glycolysis).
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This to me suggests that there may be the following areas where the body is unable to make use of fats
1- Absence of bile substance, if there is no bile there the body can't The dissolve the fat into the watery contents of the intestine, however if that was the case I think JL53563 would have had diarrhoea as well.
2- Absorption of the fatty acids have not been absorbed by the villi in the intestine - again I think if this was it, diarrhoea would happen.
3- The fatty acids were not transported from the lymphatic system into the bloodstream - but would it just sit around in the lymphatic system?
4- Fatty acids were not transported from the bloodstream to the body cells - but then the we'd know from the blood work ( and think JL would have died
by now)
5- Fat was transported to the body cells, but all of it was oxidized for energy, non was stored.
I think the majority of the explanations and various theories leans towards the last point, but i.e. because insulin levels are low, cells didn't get triggers to store the fat, just oxidise it... but where does all the energy go??
Please let me know if you think I got the above wrong