DietDoctor posted a new interview with Dr. Westman (membership page). A possible new caution for a new drug was mentioned. I have no personal experience with it, but adding that section from the transcript here:
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Are these the ones he's referring to?
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Yes, a few weeks ago FDA strengthened its warnings on them for Kidney injury. That study was mentioned on the People's Pharmacy news round-up but then hearing Dr. Westman say this about drug and diet possible interaction...thought should post it here.
https://www.drugwatch.com/2016/06/2...injury-warning/ Quote:
Jeez, is that all? Amputations, ketoacidosis, elevated risk of stroke in ONE month? Yikes! |
Yikes is right. Meanwhile...
No Clear Survival Benefit Seen Among Diabetes Drugs - But meta-analysis hampered by limitations of included studies Eight different diabetes drug classes examined in a meta-analysis failed to demonstrate improved cardiovascular or all-cause mortality compared with placebo. http://www.medpagetoday.com/endocri.../diabetes/59182 Also: Quote:
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The gastrointestinal side effects preventing some patients from using Metformin were mentioned. I really wonder if that reflects the state of their guts. |
Metformin gave my mother horrible gastric issues for years. At some point she was taking Invokana. She died of kidney and liver failure on May 28 of this year. She was 70 and recovery would have required transplants, so they sent her home on hospice. However, I cannot say that having poorly managed diabetes for 20 years wasn't what caused her organs to fail instead of the med. She wasn't in good health for years as a result of complications caused by diabetes. That and she refused to eat healthy and would only drink diet soda (no water)...I love that woman, but she was such a stubborn mule sometimes.
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I'm sorry to hear about your mother.
It's very sad when diabetics can't manage effective dietary changes. It doesn't help that there is so little societal support for diabetics not eating sugar, white flour and tons of other carbs. What I'm wondering is if a robust prebiotic/probiotic intervention or other measures to improve gut health would enable people to take Metformin. When I was diagnosed the endocrinologist prescribed Metformin, a sulfonylurea and diabetic teaching. I only took the Metformin and got a new doctor who supported a low carb diet. |
I started on regular metformin and a low carb diet. Not sure what the state of my gut was/is, but I was eating full fat yogurt with live cultures. Anyway, my gut never adjusted to the metformin even with a slow ramp up in dose. Luckily, my insurance did cover glumetza and that worked great for me. Now I take the generic glumetza (has the same special coating, not nearly as expensive), still works great.
In the beginning, I did ask about victoza and other drugs to help me lose weight/lower blood glucose as I didn't think it was happening fast enough. Thankfully, my doctor and the pharmacist counselor said just to give it more time before trying anything else. On reflection, I don't see how peeing out excess sugar can be healthy. It certainly doesn't give incentive to change one's diet, and I would imagine a lot of bladder infections are involved. |
Scary! It will just encourage people to sustain or increase their consumption of sugar, which starts being absorbed by the mucous membranes of the mouth. So there are a lot of places the sugar can feed cancer on its way through your system. I wonder if it will cause urinary leakage similar to how Olestra increased underwear sales? No thanks.
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I think there is evidence that 2 tablespoons of apple cider vinegar before each meal (not sure about the dosage) is said to mimic the effects of metformin in some people. I put it in water and find it to actually be quite tasty if diluted enough (I use the Braggs' organic). I think that would be much easier on the gut.
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Dr Eenfeldt has added a new guide:
Starting Low Carb with Diabetes Medications http://www.dietdoctor.com/low-carb/...tes-medications He covers insulin and also the limited risks with some of the pills by brand name. Quote:
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Janet, thank you for bringing up this thread, which I've overlooked until today. I've been waiting too long to join the DietDoctor membership, so today I'm heading over there to join. I've been looking at the SGLT-2 drugs, especially since Dr. Fung thinks highly of them. However, the ketoacidosis warnings leave me too startled to bring it up with my doctor. During allergy season and during injuries my numbers head up, so my doctor recently added Actos to my meds. Don't like it a bit, but in spite of all my exercise, fasting schedule, eating and drinking right, I still need help. So, half a dose of Actos it is until I can get numbers down. Thanks for the link info.
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Glad this article helped. With your Diet Doctor membership, watch Dr Westman's newer talk, LCHF and Diabetes, Theory and Clinical experience. It has a number of patient experiences...start doses, meds, how long diabetic, and how he reduces insulin in a clinic.
http://www.dietdoctor.com/member/pr...ons/westman-lcc |
Janet!!!!!! I was on invokana and went DKA with normal BG just under a year ago, at which time i was taken off the drug.
I had been on it about 15 months, when due to stress, i basically ate nothing for 3 days and promptly went DKA. It was terrifying and I spent several days in an ICU recovering. it now carries FDA warning label for type I's that it it can have this effect. i knew it was a small risk, but as a very well controlled diabetic, i never imagined it could happen without high blood sugar. the warning i got was "it might increase risk of DKA." I wish i knew it meant "can cause DKA without high BG." |
Starting with the concerns in post #46, the conclusion is that the FDA has added a "black box" warning to Invokana as of this week.
http://forum.lowcarber.org/showthre...13&page=1&pp=15 Knowing Robin's story and the high increased risk for amputations, this drug should have been pulled from market. Do you think the drug detail sales teams will highlight this warning to doctors? User be aware of risks with SGLT2 inhibitors. ********* Most of this thread is about adjusting DIABETES medications. Be aware that BLOOD PRESSURE also needs to be monitored carefully and possibly BP medications may need to be reduced. https://www.dietdoctor.com/low-carb...-blood-pressure Quote:
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In Australia: A 21 year old woman with Type I Diabetes and failing kidneys had a successful kidney and pancreas transplant. I didn't know that was possible. Do doctors in the USA offer this treatment?
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