Intermittent Fasting: Health benefits -- mechanisms?
A study in Cell:
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Unknown, but maybe all the puzzle pieces are likely there; waiting to be put together? Technical warning :) A gene: In humans is composed of approximately 8446 base pairs of A-T, G-C, and (generally) codes for one protein. The structure of a gene consists of many elements of which the actual protein coding sequence is often only a small part. These include DNA regions that are not transcribed, up to 98% of our DNA may be junk or regulatory DNA, as well as untranslated regions of the RNA. A promoter: The cauliflower mosaic virus CaMV (35S) gene is an "always on" promoter used to genetically modify plants [by activating added genes] in horticulture. Quote:
The key here is "promoters" and "enhancers" are critical parts of the complex machinery of a cell and can be enabled by outside stimuli in the biological environment. So I submit "fasting stress" or (natural nutrient energy unavailability) is likely one of these. Quote:
Epigenetic factors: Quote:
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Agreed. Food or lack of is and has always been part of the "environment," the principle of epigenetics. I've referenced it before: Biology of Belief 10th Anniversary Edition by Bruce Lipton is an excellent summary of how powerful our environment is to our mental and physical health and well being. We have the ability to create and control our environment in several ways. Something as simple as creating our attitude and daily outlook has significant health implications.
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Thanks GRB!
Ill recommend it to my DB who has Parkinson's: Quote:
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Thanks GRB. I just borrowed it from the library.
:thup: :) |
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Glucose restriction is very effective in C. elegans. In mammals, neither IF nor glucose restriction (i.e. low-carb) is conclusive with regards to longevity. The most prominent effect is on overall health. And here, low-carb works best. OK, so the premise is some form of restriction to increase lifespan. In a mechanical sense, this makes sense. The less often we use a machine (or the less stress for a continuously running machine), the longer it remains functional. In a biological sense, it doesn't. To wit, chaperone-mediate autophagy, whereby an energy substrate - ketones - stimulate clean-up of what would otherwise decrease lifespan. The more ketones, the less crud, the longer lifespan. Or at least, if lifespan was a function of crud. It's not. Health is a function of crud. OK, so the premise isn't just lifespan, it's up-to-maximum lifespan. What controls maximum lifespan? As far as anybody knows, we don't know. Whatever these experts are looking at ain't it, cuz it's all about health - up-to-maximum lifespan - not about absolute lifespan. |
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:thup: :) |
s93, glad you enjoyed it. It confirms that being mindful is very powerful in many different and positive ways.
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