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Those Zombie Fat [senescent] Cells

We all know being obese can make one sick, but also old?

Quote:

In their new study, they sought to verify these observations by testing the effect of the same mixture of senolytics on human adipose tissue. Obtained from obese people, these tissues show a strong accumulation of senescent cells [3]. These cells release a variety of factors such as pro-inflammatory cytokines and chemokines, which contribute to the physical dysfunction of tissues and organs during aging.

Senolytics are not yet available for human trials, but fasting has been shown to promote both autophagy and apoptosis. Calorie restricted and low-carb diets are also being looked at.

http://www.longlonglife.org/en/tran...-healthy-aging/

https://www.leafscience.org/senolytics/

Makes sense to me. The ways people get fat are all bad for you.

Mayo clinic along with Wake forest just reported a 3 week trial with 24 cystic fibrosis patients to determine the safety of giving a leukemia drug along with quercerin. All senescence cells were eliminated within 24 hours. Some improvement in physical and mental abilities. Very limited in scope. Some indication that the researchers are going for human trials with other diseases.

Here is website and the participants were 14 not 24.
https://www.sciencedaily.com/releas...90107134944.htm