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-   -   Diabetes & Metabolic Syndrome: Clinical Research & Reviews - March April 2019 (http://forum.lowcarber.org/showthread.php?t=482833)

s93uv3h Wed, Jul-24-19 03:16

Diabetes & Metabolic Syndrome: Clinical Research & Reviews - March April 2019
 
Diabetes & Metabolic Syndrome: Clinical Research & Reviews - March April 2019

Abstract

It has been established that there is a correlation between Alzheimer's disease and apolipoprotein E, specifically the ApoE4 genetic variant. However, the correlation between Apoe4, insulin resistance and metabolic syndrome (MetS) pathologies still remains elusive. As apolipoprotein E has many important physiological functions, individuals with the ApoE4 allele variant, also known as the Alzheimer's disease gene, are primarily at a greater risk for physiological consequences, specifically cognitive impairment (Chan et al., 2016). In this case study, a 71-year old female, heterozygous for ApoE4 with a family history of Alzheimer's Disease (AD) and the dual diagnosis of mild AD/metabolic syndrome (MetS) was placed on a 10-week nutrition protocol purposed at raising plasma ketones through carbohyrdrate restricted, high fat ketogenic diet (KD), time- restricted eating and physical/cognitive exercise. Primary biomarkers for MetS were measured pre/mid-/post intervention. The MoCA (Montreal Cognitive Assessment) was administered pre/post intervention by a licensed clinical therapist. The results were statistically significant. The HOMA-IR decreased by 75% from 13.9 to 3.48. Triglycerides decreased by 50% from 170mg/dL to 85mg/dL. VLDL dropped by 50% from 34mg/dL to 17mg/dL, and HgA1c decreased from 5.7% to 4.9%. The baseline MoCA score was 21/30; post treatment score was 28/30. The significant results in both MetS biomarkers and the MoCA score suggest that a ketogenic diet may serve to rescue cognition in patients with mild AD. The results of this case study are particularly compelling for ApoE4 positive (ApoE4+) subjects as ketogenic protocols extend hope and promise for AD prevention.

Dodger Wed, Jul-24-19 05:37

That's a very interesting N=1 study. If an Alzheimer drug had that result, it would be called a miracle cure.

GRB5111 Wed, Jul-24-19 07:18

While this is an N=1, I wonder what a preventive keto protocol would do for those who have been confirmed with the ApoE4 allele variant? Could it serve to delay or reduce Alzheimer's symptoms?


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