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-   -   Obesity Could Be Prevented by Blocking Single Gene (http://forum.lowcarber.org/showthread.php?t=481681)

Demi Thu, Dec-06-18 02:41

Obesity Could Be Prevented by Blocking Single Gene
 
Quote:
Obesity Could Be Prevented by Blocking Single Gene

Studies in mice by an international team of scientists suggest that inhibiting a single gene could combat obesity and related metabolic disorders by allowing people to eat as much as they want without putting on weight. When the Flinders University-led team deleted the gene, known as regulator of calcineurin 1 (RCAN1), in mice fed a high-fat diet (HFD), the animals didn’t put on weight because their whole body metabolic rate increased.



https://www.genengnews.com/news/blo...u-can-eat-pill/

GRB5111 Thu, Dec-06-18 08:53

Hmmm, I eat a high-fat diet (relatively speaking), and I don't put on weight. Somehow, I must have turned off my obesity gene . . . . :bash:

mike_d Thu, Dec-06-18 09:41

Quote:
Originally Posted by GRB5111
Hmmm, I eat a high-fat diet (relatively speaking), and I don't put on weight. Somehow, I must have turned off my obesity gene . . . . :bash:
Yes, surprising even some PhD's think "of course, fat makes you fat."

As regards rodents; the smaller the animal the higher its MBR.

That being said, "knocking out a gene" is rather trivial now using Cas9, there are even DIY experiment kits for sale on Amazon. Tags are available now for $45. Target Gene editing in an adult human is still difficult and experimental, requiring a modified vector such as an adenovirus. It's not FDA approved yet in the US, even though a few people are doing it.

s93uv3h Thu, Dec-06-18 10:34

Quote:
Originally Posted by mike_d
"of course, fat makes you fat."
or inflamed - re: omega 3 / omega 6 ratio.

teaser Thu, Dec-06-18 11:43

There's no question a high fat diet makes people fat. The question is, which one?


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