The impact of dietary protein intake on longevity and metabolic health
 

Just want to point out fish/chicken has higher amount of methionine than red meat. Also Japanese(longevity) diet is rich in sea food which contradicts to this study.



The impact of dietary protein intake on longevity and metabolic health


https://www.ebiomedicine.com/articl...0239-7/fulltext

Abstract
Lifespan and metabolic health are influenced by dietary nutrients. Recent studies show that a reduced protein intake or low-protein/high-carbohydrate diet plays a critical role in longevity/metabolic health. Additionally, specific amino acids (AAs), including methionine or branched-chain AAs (BCAAs), are associated with the regulation of lifespan/ageing and metabolism through multiple mechanisms. Therefore, methionine or BCAAs restriction may lead to the benefits on longevity/metabolic health. Moreover, epidemiological studies show that a high intake of animal protein, particularly red meat, which contains high levels of methionine and BCAAs, may be related to the promotion of age-related diseases. Therefore, a low animal protein diet, particularly a diet low in red meat, may provide health benefits. However, malnutrition, including sarcopenia/frailty due to inadequate protein intake, is harmful to longevity/metabolic health. Therefore, further study is necessary to elucidate the specific restriction levels of individual AAs that are most effective for longevity/metabolic health in humans.

If these are more people worried over the impact of branched chain amino acids, leucine in particular, upregulating mTOR, they need to think about the fact that insulin, stimulated by their high carbohydrate diet, upregulates mTOR even higher and for longer, possibly all day long if a person eats/snacks on carbs throughout the day as they likely will due to elevated insulin repeatedly stimulating hunger. I prefer to kick up mTOR a brief time at each meal with a nice piece of meat, let it do its muscle-building growth stimulation, and then let it go back down with no excess insulin from carbs to over-activate it. How some of these researchers manage to point a finger at the pulsatile mTOR stimulating effects of protein while completely overlooking the effect of insulin on it is puzzling to me. I guess because of their belief in the badness of meat and goodness of carbs. And I agree with the concern about muscle loss if not enough protein is consumed. We need mTOR active at times to prevent that, especially as we age to avoid sarcopenia. We just don't need it on all the time.

Leucine, isoleucine and valine are essential amino acids. Some studies I've read say you need them, you need them from animal sources and they extend your life span.

Who you gonna believe?

Bob