Diet on vLDL Trial
 

Effect of protein, unsaturated fat, and carbohydrate intakes on plasma apolipoprotein B and VLDL and LDL containing apolipoprotein C-III: results from the OmniHeart Trial

Background:Plasma apolipoprotein B (apo B) and VLDL and LDL with apolipoprotein C-III (apo C-III) are independent risk factors for cardiovascular disease (CVD). Dietary intake affects lipoprotein concentration and composition related to those apolipoproteins.

Objective:We studied differences in apo B lipoproteins with and without apo C-III after 3 healthy diets based on the Dietary Approaches to Stop Hypertension Trial diet.

Design:Healthy participants (n = 162) were fed each of 3 healthy diets for 6 wk in a crossover design. Diets differed by emphasis of either carbohydrate (Carb), unsaturated fat (Unsat), or protein (Prot). Blood was collected at baseline and after diets for analysis.

Results:Compared with the Carb diet, the Prot diet reduced plasma apo B and triglycerides in VLDL with apo C-III (16%, P = 0.07; 11%, P = 0.05, respectively) and apo B in LDL with apo C-III (16%, P = 0.04). Compared with the Unsat diet, the Prot diet reduced triglycerides in VLDL with apo C-III (16%, P = 0.02). Compared with baseline (subjects' usual diet was higher in saturated fat), the Prot diet reduced apo B in LDL with apo C-III (11%, P = 0.05), and all 3 diets reduced plasma total apo B (6–10%, P < 0.05) and apo B in the major type of LDL, LDL without apo C-III (8–10%, P < 0.01). All 3 diets reduced the ratio of apo C-III to apo E in VLDL.

Conclusions:Substituting protein for carbohydrate in the context of a healthy dietary pattern reduced atherogenic apo C-III–containing LDL and its precursor, apo C-III–containing VLDL, resulting in the most favorable profile of apo B lipoproteins. In addition, compared with a typical high-saturated fat diet, healthy diets that emphasize carbohydrate, protein, or unsaturated fat reduce plasma total and LDL apo B and produce a lower more metabolically favorable ratio of apo C-III to apo E.

http://www.ajcn.org/cgi/content/abstract/87/6/1623

---------------------------------

They DID NOT test to reach this conclusion:

"In addition, compared with a typical high-saturated fat diet, healthy diets that emphasize carbohydrate, protein, or unsaturated fat reduce plasma total and LDL apo B and produce a lower more metabolically favorable ratio of apo C-III to apo E. "

Yeah, you're right. :p

I am starting to think that everyone who gets any form of advanced degree should take a class in the Fruit Department.

Course: Fruits 501
Course Title: The difference between apples and oranges.
Description of Course: Apples and oranges are inherently different. These differences are explored and techniques to discern the differences are discussed. Proof that no amount of interpretation will turn apples into oranges or oranges into apples is given.

There was their first mistake. The DASH is not a healthy diet.

ah, the old healthy diet, right there under our noses all this time...