kebaldwin
Sat, Jun-16-07, 19:45
role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas.
Study findings on obesity and diabetes risk factors are outlined in reports from Harvard University, Department of Nutrition
NewsRx.com
06-15-07
Fresh data on obesity and diabetes are presented in the report "The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas." According to a study from the United States, "Recent evidence indicates that obesity and related metabolic abnormalities are associated with increased incidence or mortality for a number of cancers, including those of the colon, prostate, and pancreas. Obesity, physical inactivity, visceral adiposity, hyperglycemia, and hyperinsulinemia are relatively consistent risk factors for colon cancer and adenoma."
"Also, patients with type 2 diabetes mellitus have a higher risk of colon cancer. For prostate cancer, the relationship to obesity appears more complex. Obesity seems to contribute to a greater risk of aggressive or fatal prostate cancer but perhaps to a lower risk of nonaggressive prostate cancer. Furthermore, men with type 2 diabetes mellitus are at lower risk of developing prostate cancer. Long-standing type 2 diabetes increases the risk of pancreatic cancer by approximately 50%. Furthermore, over the past 6 years, a large number of cohort studies have reported positive associations between obesity and pancreatic cancer. Together with data from prediagnostic blood specimens showing positive associations between glucose levels and pancreatic cancer up to 25 years later, sufficient evidence now supports a strong role for diabetes and obesity in pancreatic cancer etiology. The mechanisms for these associations, however, remain speculative and deserve further study," wrote E. Giovannucci and colleagues, Harvard University, Department of Nutrition.
The researchers concluded: "Hyperinsulinemia may be important, but the role of oxidative stress initiated by hyperglycemia also deserves further attention."
Giovannucci and colleagues published the results of their research in Gastroenterology (The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas. Gastroenterology, 2007;132(6):2208-25).
For additional information, contact E. Giovannucci, Harvard School of Public Health, Dept. of Nutrition, Boston, Massachusetts USA.
The publisher of the journal Gastroenterology can be contacted at: W B Saunders Co., Independence Square West Curtis Center, Ste. 300, Philadelphia, PA 19106-3399, USA.
Keywords: United States, Boston, Obesity and Diabetes Risk Factors, Bariatrics, Colon Cancer, Colon Carcinoma, Diabetes Mellitus, Endocrinology, Gastroenterology, Immunization, Obesity, Obesity and Diabetes, Oncology, Pancreas, Prostate Cancer, Prostate Cancer Vaccine, Prostatic Neoplasms, Type 2 Diabetes, Vaccination.
This article was prepared by Cancer Weekly editors from staff and other reports. Copyright 2007, Cancer Weekly via NewsRx.com.
To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .
http://www.lef.org/news/LefDailyNews.htm?NewsID=5485&Section=NUTRITION
Study findings on obesity and diabetes risk factors are outlined in reports from Harvard University, Department of Nutrition
NewsRx.com
06-15-07
Fresh data on obesity and diabetes are presented in the report "The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas." According to a study from the United States, "Recent evidence indicates that obesity and related metabolic abnormalities are associated with increased incidence or mortality for a number of cancers, including those of the colon, prostate, and pancreas. Obesity, physical inactivity, visceral adiposity, hyperglycemia, and hyperinsulinemia are relatively consistent risk factors for colon cancer and adenoma."
"Also, patients with type 2 diabetes mellitus have a higher risk of colon cancer. For prostate cancer, the relationship to obesity appears more complex. Obesity seems to contribute to a greater risk of aggressive or fatal prostate cancer but perhaps to a lower risk of nonaggressive prostate cancer. Furthermore, men with type 2 diabetes mellitus are at lower risk of developing prostate cancer. Long-standing type 2 diabetes increases the risk of pancreatic cancer by approximately 50%. Furthermore, over the past 6 years, a large number of cohort studies have reported positive associations between obesity and pancreatic cancer. Together with data from prediagnostic blood specimens showing positive associations between glucose levels and pancreatic cancer up to 25 years later, sufficient evidence now supports a strong role for diabetes and obesity in pancreatic cancer etiology. The mechanisms for these associations, however, remain speculative and deserve further study," wrote E. Giovannucci and colleagues, Harvard University, Department of Nutrition.
The researchers concluded: "Hyperinsulinemia may be important, but the role of oxidative stress initiated by hyperglycemia also deserves further attention."
Giovannucci and colleagues published the results of their research in Gastroenterology (The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas. Gastroenterology, 2007;132(6):2208-25).
For additional information, contact E. Giovannucci, Harvard School of Public Health, Dept. of Nutrition, Boston, Massachusetts USA.
The publisher of the journal Gastroenterology can be contacted at: W B Saunders Co., Independence Square West Curtis Center, Ste. 300, Philadelphia, PA 19106-3399, USA.
Keywords: United States, Boston, Obesity and Diabetes Risk Factors, Bariatrics, Colon Cancer, Colon Carcinoma, Diabetes Mellitus, Endocrinology, Gastroenterology, Immunization, Obesity, Obesity and Diabetes, Oncology, Pancreas, Prostate Cancer, Prostate Cancer Vaccine, Prostatic Neoplasms, Type 2 Diabetes, Vaccination.
This article was prepared by Cancer Weekly editors from staff and other reports. Copyright 2007, Cancer Weekly via NewsRx.com.
To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .
http://www.lef.org/news/LefDailyNews.htm?NewsID=5485&Section=NUTRITION