Active Low-Carber Forums
Atkins diet and low carb discussion provided free for information only, not as medical advice.
Home Plans Tips Recipes Tools Stories Studies Products
Active Low-Carber Forums
A sugar-free zone


Welcome to the Active Low-Carber Forums.
Support for Atkins diet, Protein Power, Neanderthin (Paleo Diet), CAD/CALP, Dr. Bernstein Diabetes Solution and any other healthy low-carb diet or plan, all are welcome in our lowcarb community. Forget starvation and fad diets -- join the healthy eating crowd! You may register by clicking here, it's free!

Go Back   Active Low-Carber Forums > Main Low-Carb Diets Forums & Support > Low-Carb Studies & Research / Media Watch > LC Research/Media
User Name
Password
Register FAQ Members Calendar Mark Forums Read Search Gallery My P.L.A.N. Survey


Reply
 
Thread Tools Display Modes
  #1   ^
Old Wed, Feb-07-18, 08:42
teaser's Avatar
teaser teaser is offline
Senior Member
Posts: 12,296
 
Plan: ketosis/IF
Stats: 190/157.2/154 Male 67inches
BF:
Progress: 91%
Location: Ontario
Default Fructose metabolism liver vs. intestine

https://www.sciencedaily.com/releas...80206140645.htm

Quote:
Princeton University researchers report that in mice, fructose, a sugar found in fruit, is processed mainly in the small intestine, not in the liver as had previously been suspected. Sugary drinks and processed high-sugar foods overwhelm the small intestine and spill into the liver for processing. Additionally, the authors learned that the ability of the small intestine to process fructose is higher after a meal. The work appears February 6 in the journal Cell Metabolism.

Evidence from previous animal and human studies has shown that excessive sugar ingestion can be harmful, especially to the liver. Chronic over-consumption can lead to obesity and foster insulin resistance that can progress to diabetes; it also can contribute to non-alcoholic fatty liver disease, which can lead to cirrhosis or liver cancer.

"There is a fundamental physiological difference in how smaller and larger amounts of sugar are processed in the body," explains Joshua D. Rabinowitz of the Lewis-Sigler Institute for Integrative Genomics at Princeton University, whose laboratory led the study. The prior view was that the liver processes all ingested sugar. But this study showed that more than 90 percent of the fructose was cleared by the small intestine in mice.

"We can offer some reassurance -- at least from these animal studies -- that fructose from moderate amounts of fruits will not reach the liver," he says. However, the small intestine probably starts to get overwhelmed with sugar halfway through a can of soda or large glass of orange juice.

In the study, Rabinowitz and his colleagues studied the path of isotope-labeled fructose through the digestive systems of laboratory mice. The researchers observed that excess fructose that is not absorbed by the small intestine continues through the intestine into the colon. As a consequence, it also comes into contact with the natural microbiotic flora of the large intestine and colon, known as the microbiome.

"The microbiome is designed to never see sugar," Rabinowitz says. "One can eat an infinite amount of carbohydrates, and there will be nary a molecule of glucose that enters the microbiome. But as soon as you drink the soda or juice, the microbiome is seeing an extremely powerful nutrient that it was designed to never see."

While the study did not show that fructose influences the microbiome, the authors suggest an effect is likely and should be studied further to learn more about the biological consequences of high sugar intake.

The investigators also found that the small intestine clears fructose more efficiently after a meal. "We saw that feeding of the mice prior to the sugar exposure enhanced the small intestine's ability to process fructose," said Rabinowitz. "And that protected the liver and the microbiome from sugar exposure." The researchers theorize that in a fasting state, such as upon awakening or in the mid-afternoon, one is extra vulnerable to fructose due to a lessened ability to process it in the small intestine.

Although the study was conducted in mice, Rabinowitz encourages "the most old-fashioned advice in the world" for humans. Limit sweets to moderate quantities after meals, and do not have sweet drinks away from meal time.




So, there's still a problem of excess fructose in the liver, but what constitutes excess fructose for the liver itself is smaller than we thought.
Reply With Quote
Sponsored Links
  #2   ^
Old Thu, Feb-08-18, 05:18
WereBear's Avatar
WereBear WereBear is offline
Posts: 10,369
 
Plan: Epi-Paleo/IF
Stats: 220/161/150 Female 67
BF:
Progress: 84%
Location: USA
Default

Quote:
Additionally, the authors learned that the ability of the small intestine to process fructose is higher after a meal.


Which is why I can have fruit as dessert, but not as a "snack." In fact, the more we know about how our bodies work, the less snacking works at all.
Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off



All times are GMT -6. The time now is 18:35.


Copyright © 2000-2018 Active Low-Carber Forums @ forum.lowcarber.org
Powered by: vBulletin, Copyright ©2000 - 2018, Jelsoft Enterprises Ltd.