Originally Posted by teaser
A big problem here is that there's the hyper response of insulin secretion, and then the hyper response to insulin. In the A to Z study, carbohydrate restriction seemed to be more effective for people who were insulin resistant. So is carbohydrate restriction not the way to go if you're insulin sensitive? I don't know if that's true, for somebody whose fat tissue is very insulin sensitive, the absolute level of insulin needed to promote fat loss might be considerably lower. So things get muddy, insulin has an undeniable effect in individuals, it's just that the required dose for a given effect has massive variability from individual to individual.
Insulin-degrading enzyme in the liver, that's the key. For same pancreas insulin output, variation in IDE will result in variation in blood insulin level. So let's find out why there's more or less IDE in the liver, fix it. First it's diet, right? But once we've done that, if there's still a problem, we can't blame any of it on diet anymore - it's fixed.
Even Feinman's work on keto and cancer shows there's something else going on besides how much carbs we eat. For same diet, some just didn't respond at all, while others responded fine. But here, it's even more clear there's something else - we're dealing with cancer.
In the A-TO-Z experiment, it's likely that's pretty much what's going on. Varying degrees of something elses. The more other things, the more potent other things, the greater the effect on compliance. It's the same diet, it's just a different internal millieu. Not DNA either, that argument is refuted, i.e. how could an entire population's DNA mutate within their lifetime? No, it's epigenetics - environment - but we just fixed the main culprit - diet - so there's obviously something else going on.
Another thing is stress, we all talk about stress this and stress that and how important it is to stay calm and whatever. Take a step back, think about this. If the principle whereby there could be something else besides diet that affects insulin is true, then isn't it also equally possible this same principle applies to other hormones as well - stress hormones and some other agent besides a "stressful situation"? Imagine this. We're stressed cuz some dummy broke something, our response is way over the top, we break out, get really nervous, can't concentrate, get depressed, indigestion, get weak, you name it, it's all happening. Now, it's just a broken cup. But even if it was a serious thing, look at the response, it's way disproportionate. No way this is normal. This ain't DNA either. There's obviously something else going on, something that keeps us primed and ready to jump at the tiniest event. Doesn't it sound pretty much exactly like our different individual response to carbs and insulin?